Introduction

3-Bromopropyne, also known as 1-bromo-2-propyne, is an organic compound. The following is a brief introduction to its properties, uses, manufacturing methods and safety information:

Quality:

- It has a lower density, with a value of about 1.31 g/mL.

- 3-Bropropyne has a pungent odor.

- It can be soluble in some organic solvents such as ethanol and ether.

Use:

- 3-Broproyne is mainly used as a reagent in organic synthesis reactions, for example it can participate in metal-catalyzed cross-coupling reactions for the synthesis of organic compounds.

- It can also be used as a starting material for alkynes, e.g. for the synthesis of alkynes or other functionalized alkynes.

Method:

- 3-Bromopropyne can be obtained by the reaction of bromoacetylene and ethyl chloride under alkaline conditions.

- This is done by mixing bromoacetylene and ethyl chloride and adding a certain amount of alkali (such as sodium carbonate or sodium bicarbonate).

- At the end of the reaction, pure 3-bromopropynne is obtained by distillation and purification.

Safety Information:

- 3-Bropropyne is a toxic and irritating substance that requires proper personal protective equipment (PPE) to be worn when operating.

- It should avoid contact with oxidants, strong alkalis, and strong acids to avoid dangerous reactions.

- Comply with relevant safety operating procedures during use and storage.

- When handling 3-bromopropyne, ensure good ventilation and avoid inhaling its vapours or coming into contact with the skin and eyes.

Product Name and CAS Number

Propargyl bromide 3 Bromopropyne | CAS 106 96 7

One Line Sourcing Position

High purity Propargyl bromide solution for alkynylation reactions and organic synthesis building blocks.

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Specification

Form: 80 percent solution in toluene or 95 percent pure stabilized grade
Purity of active content: 80.0 plus minus 2.0 percent (as solution)
Appearance: Clear colorless to pale yellow to amber liquid
Density at 20 deg C: 1.35 to 1.40 g per mL (for 80 percent solution)
Water content Karl Fischer: 0.10 percent maximum
Stabilizer: 0.5 to 1.0 percent propylene oxide or other inhibitor
Free bromine: 0.10 percent maximum
Residue on evaporation: 2.0 percent maximum
Stock Status: In Stock in US warehouse and China hub (as 80 percent in toluene)

Available Quantity and Lead Time

Regular supply: 1 kg to 15 metric tons per shipment
Lead time: 3 to 5 days for standard packaging; bulk orders require 7 to 10 days

Document Support

COA SDS HPLC chromatogram NMR spectrum Mass spectrum MS available upon request

Application

Propargyl bromide is a highly reactive alkylating agent used to introduce the propargyl (ethynylmethyl) group into organic molecules. In pharmaceutical synthesis, it serves as a key building block for the preparation of antiviral drugs (e.g., efavirenz, nevirapine), antifungal agents, and enzyme inhibitors containing alkyne moieties. The compound is widely employed in the synthesis of heterocycles such as pyrazoles, triazoles, oxazoles, and furans via cycloaddition and coupling reactions. In agrochemical research, propargyl bromide is used to produce acaricides, fungicides, and herbicides with terminal alkyne functionality. It is also a precursor for the synthesis of alkynyl silanes, alkynyl stannanes, and other organometallic reagents used in cross coupling (Sonogashira, Cadiot Chodkiewicz) reactions. In material science, propargyl bromide functionalizes polymers, dendrimers, and carbon surfaces for click chemistry applications (copper catalyzed azide alkyne cycloaddition). Additionally, it finds use in the preparation of alkynylated nucleosides for DNA labeling probes and as a starting material for propargyl alcohol derivatives. Academic research laboratories utilize it extensively for alkyne natural product synthesis and chemical biology studies.

Custom Synthesis Support

We offer custom synthesis for propargyl bromide derivatives including propargyl amines, propargyl ethers, and isotopically labeled versions. Share your technical datasheet for feasibility review.

Packaging and Shipping

Available in 1 kg, 5 kg, 25 kg, or 200 kg steel drums with PTFE lined closures. All packages are under dry nitrogen atmosphere to prevent decomposition. Custom packaging such as ampoules or smaller units for R&D is supported. Fastest dispatch within 7 days after order confirmation. Propargyl bromide is a corrosive, flammable, and light sensitive material. Class 3 flammable liquid with Class 8 corrosive subsidiary risk, UN 2924, PG II. Store in a cool, dark place away from moisture and light.

Why XinChem

XinChem provides propargyl bromide with consistent active content and strict stabilizer control for US customers. Our ISO 9001 certified facility monitors every batch by GC and active bromine titration, ensuring reliable reactivity for alkynylation reactions. We maintain a buffer stock of 5 metric tons in US warehouses for emergency deliveries within 48 hours. Each order includes a full documentation package: COA, SDS, GC chromatograms, and NMR spectra accessible through our online portal. Our technical support team assists with handling precautions, decomposition prevention, and regulatory compliance including TSCA, EINECS, and DEA precursor monitoring (where applicable). For contract customers, we offer quarterly price locks and consignment inventory to reduce supply chain risk. Trusted by over 150 pharmaceutical discovery groups and fine chemical companies in North America. We also provide free sample evaluation for qualified R&D projects and a price match guarantee against any valid competitor quote for equivalent quality. Additionally, we offer custom dilution in alternative solvents (e.g., dichloromethane, THF) upon request.

FAQ

Q1 How should propargyl bromide be stored to prevent decomposition?
A Store in a cool, dark place at 2 to 8 deg C. Keep under inert atmosphere (nitrogen or argon) and away from light, moisture, and strong nucleophiles. Shelf life is 6 to 12 months depending on stabilizer content.

Q2 What purity grades and solvents do you supply?
A Standard grade is 80 percent solution in toluene. We also offer 95 percent pure (unstabilized) for immediate use, and custom solutions in THF, DCM, or DMF.

Q3 Is propargyl bromide stable in stainless steel containers?
A 316 stainless steel is suitable for short term storage. For long term, use PTFE lined or glass lined containers. Avoid copper, aluminum, and zinc.

Q4 Do you provide sample quantities for reaction screening?
A Yes, free samples of 100 mL (80 percent solution) are available for qualified US companies. Shipping fee applies for small quantities due to hazardous nature.

Q5 What safety measures are required when handling propargyl bromide?
A Use in a fume hood with full PPE: nitrile gloves, lab coat, and safety goggles. It is a lachrymator and corrosive. Avoid skin contact and inhalation.

Q6 Can you supply propargyl bromide with a higher stabilizer content for extended shelf life?
A Yes, we can increase propylene oxide or other inhibitor concentration. Please specify your required stabilizer level and storage duration.