Tea polyphenol(CAS#84650-60-2)

Chemical Property:

Molecular Formula	C22H18O11
Molar Mass	458.37
Density	1.90±0.1 g/cm3(Predicted)
Melting Point	222-224°C
Boling Point	909.1±65.0 °C(Predicted)
Specific Rotation(α)	D -185 ±2°(ethanol)
Flash Point	320°C
Water Solubility	Soluble in ethanol, dimethyl formamide, water.
Solubility	Soluble in water.
Vapor Presure	3.71E-35mmHg at 25°C
Appearance	White to pale pink powder
Color	White to Light Brown
Merck	14,3526
pKa	7.75±0.25(Predicted)
Storage Condition	2-8°C
Stability	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Refractive Index	-175.5 ° (C=1, EtOH)
MDL	MFCD00075940
Physical and Chemical Properties	White crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tea Tea.
Use	The food industry is used for anti-oxidation, fresh-keeping and deodorizing, the pharmaceutical industry is used for antibacterial, anti-cancer and anti-aging, and the daily chemical products are used as special functional additives.
In vitro study	(-)-Epigallocatechin gallate has potent antioxidant effects in healthy cells and reduces oxidative damage, acts as an anti-angiogenic and anti-tumor agent, and is also a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate has a variety of anti-tumor effects, such as anti-proliferation, anti-angiogenesis, blocking various cancer cell transformation, cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate by regulating multiple tumor-associated cell signaling pathways (regulating the expression levels of key signaling proteins, such as nuclear factor-κB, MAPKs, and activator protein -1,EGFR,IGF,COX-2) affect the methylation of tumor genes and the binding of ligands to membrane receptors to exert anti-tumor effects. (-)-Epigallocatechin gallate has an immunomodulatory effect. Many types of immune cells are affected to varying degrees by (-)-Epigallocatechin gallate in both the innate and adaptive immune systems. Among these effects, significant effects on T cells have been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and cytokine production. Studies based on animal models of autoimmune disease reported that green tea/EGCG treatment improved the animal’s condition. (-)-Epigallocatechin gallate has anti-infective activity. The antiviral activity of (-)-Epigallocatechin gallate, produced by different modes of activation, has been demonstrated in many species of viruses, such as retroviruses, Orthomyxoviridae and Flaviviridae, also included are important human pathogenic bacteria such as the human immunodeficiency virus, influenza A virus, and hepatitis C virus.

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Product Detail

Product Tags

Safety Description	24/25 – Avoid contact with skin and eyes.
WGK Germany	2
RTECS	KB5200000
FLUKA BRAND F CODES	10-23
HS Code	29339900
Toxicity	LD50 oral in mouse: 2170mg/kg

Introduction

(-)-Epigallocatechin-3-gallate, also known as (-)-EGCG, is a naturally occurring compound derived from tea leaves.Properties:(-)-Epigallocatechin-3-gallate is a white crystalline powder that is stable at room temperature. It also exhibits biological activities such as anti-inflammatory, anti-tumor, antibacterial properties, and inhibition of platelet aggregation.Uses:It is considered one of the most important active components in tea and can provide a variety of health benefits. It has anti-cancer, antioxidant, blood pressure-lowering, blood sugar-lowering, and cholesterol-lowering effects.Preparation:(-)-Epigallocatechin-3-gallate can be prepared by extracting (-)-epigallocatechin from tea leaves and then esterifying it with gallic acid. The specific preparation method can be optimized according to actual needs.Safety Information:(-)-Epigallocatechin-3-gallate is widely regarded as safe, and there have been no reports of harmful effects on humans. Excessive intake may cause adverse reactions in some individuals. Therefore, using it in moderation is safer. Specific groups such as pregnant women and children should use it under a doctor’s guidance.

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