tert-Butyl thiazol-4-ylcarbamate(CAS#1235406-42-4)

Introduction

N-Boc-4-aminothiazole is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of N-Boc-4-aminothiazole:Quality:- N-Boc-4-aminothiazole is a solid, white crystalline powder at room temperature.- It has high thermal stability and solubility, and is soluble in common solvents.Use:- N-Boc-4-aminothiazole is widely used in the field of organic synthesis, mainly as an intermediate or starting material.Method:- There are many preparation methods for N-Boc-4-aminothiazole, and the commonly used method is to introduce a BOC protecting group on the 4-position methyl group of aminothiazole.- The specific preparation method can be a chemical reaction, such as the reaction of N-carboximide with aminothiazole, and then the target product can be obtained through a deprotection reaction.Safety Information:- N-Boc-4-aminothiazole is an organic compound, which has certain potential hazards, and it is necessary to pay attention to safety during operation.- There are no clear reports of toxicity and basic precautions and measures for general laboratory operations are required.- Avoid contact with skin and eyes, and avoid inhalation or ingestion.- When in use or storage, keep it in a dry, cool, and well-ventilated place, away from fire and flammable materials.

Application
tert-Butyl thiazol-4-ylcarbamate (CAS 1235406-42-4) is a Boc-protected aminothiazole building block widely used in medicinal chemistry and pharmaceutical R&D. The thiazole ring is a privileged scaffold in drug discovery, and the Boc group enables selective deprotection under mild acidic conditions to reveal the free amine for further functionalization. This intermediate is essential for the synthesis of kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, antibacterial compounds, and anti-inflammatory drug candidates. Its derivatives have shown promise in treating cancer, autoimmune diseases, and infectious disorders. The rigid, electron-rich thiazole core enhances target binding affinity and metabolic stability. Researchers also utilize this building block for constructing heterocyclic libraries via amide coupling, urea formation, and cross-coupling reactions. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity tert-Butyl thiazol-4-ylcarbamate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.