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thiazolo[5,4-c]pyridin-2-amine(CAS#108310-79-8)

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Introduction

Thiazo[5,4-C]2-aminopyridine is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:Quality:- Appearance: Thiazo[5,4-C]2-aminopyridine is a white solid.- Solubility: It is soluble in organic solvents such as methylene chloride and dimethyl sulfoxide at room temperature, but insoluble in water.Use:- Chemical research: thiazolo[5,4-C]2-aminopyridine is used as an intermediate in organic synthesis and can be used in the synthesis of other organic compounds.Method:There are various methods for the synthesis of thiazolo[5,4-C]2-aminopyridine, and one of the commonly used synthetic routes is to be carried out through a multi-step reaction as follows:Cyanogen chloride is reacted with thiazole or its derivatives to obtain the corresponding thiazole acetic acid.Thiazole acetic acid is reacted with acyl chloride to produce thiazole acetyl chloride.Thiazole acetyl chloride is reacted with pyridine to give thiazolo[5,4-C]2-aminopyridine.Safety Information:The safety information of thiazolo[5,4-C]2-aminopyridine lacks detailed studies and requires appropriate laboratory safety measures when using it. Its dust may be irritating to the respiratory system, skin and eyes. Good laboratory practices should be followed when operating, including wearing protective gloves, goggles, and respiratory protective equipment. Thiazo[5,4-C]2-aminopyridine should be stored in a dry, well-ventilated place, away from ignition and oxidants. If necessary, consult a chemist or relevant safety literature for further details and guidance.

Application
Thiazolo[5,4-c]pyridin-2-amine (CAS 108310-79-8) is a privileged heterocyclic scaffold extensively used in medicinal chemistry and drug discovery. Its fused thiazole-pyridine core provides a rigid, electron-rich template that enhances target binding affinity and metabolic stability. The free amino group at the 2-position enables facile derivatization via amidation, sulfonylation, and urea formation, allowing rapid construction of diverse drug-like libraries. This building block is a key intermediate for the synthesis of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including PI3K, CDK, BTK, and EGFR inhibitors. It also serves as a precursor for antiviral, antibacterial, and antifungal agents. Its derivatives have demonstrated potent antiproliferative activity against various cancer cell lines. High purity ensures reproducible results in high-throughput screening, structure-activity relationship (SAR) studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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