1-Chloro-3,4-difluorobenzene(CAS#696-02-6)
| Risk Codes | R10 - Flammable R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Note | Flammable |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
3,4-Difluorochlorobenzene is an organic compound containing fluorine and chlorine. The following is an introduction to its properties, uses, manufacturing methods, and safety information:Quality:- Appearance: 3,4-Difluorochlorobenzene is a colorless to light yellow liquid.- Solubility: 3,4-Difluorochlorobenzene is soluble in organic solvents, such as alcohols and ethers, but insoluble in water.Use:- Solvent: With its good solubility, 3,4-difluorochlorobenzene can be used as a solvent in industrial fields such as organic synthesis, coatings and inks.Method:- 3,4-Difluorochlorobenzene can be prepared by fluorination, chlorination, and aromatic substitution reactions. The specific preparation method depends on the number of compounds and the purity requirements.Safety Information:- 3,4-Difluorochlorobenzene should be stored tightly sealed and avoid contact with ignition sources, oxidants and strong acids.- When handling 3,4-difluorochlorobenzene, wear protective gloves and goggles to avoid skin and eye contact.- Avoid inhaling vapors of 3,4-difluorochlorobenzene and move immediately to a place with fresh air if accidental inhalation causes discomfort.- In case of exposure or accidental ingestion, seek medical attention as soon as possible and bring a container or label for your doctor's reference.
Application
1-Chloro-3,4-difluorobenzene (CAS 696-02-6) is a high-purity fluorinated aromatic building block widely used as a key intermediate in pharmaceutical and agrochemical research. Its electron-withdrawing chlorine and fluorine substituents enable regioselective nucleophilic aromatic substitution and cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig), facilitating rapid construction of complex drug-like scaffolds. In medicinal chemistry, it serves as a precursor for fluoroquinolone antibiotics, anticancer agents, and antifungal compounds. In crop protection, this intermediate is utilized to synthesize selective herbicides, fungicides, and insecticides with enhanced metabolic stability and environmental safety. Additionally, it is employed in the production of liquid crystal materials, fluorinated polymers, and specialty dyes. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
