1-(trimethylsilyl)prop-1-yne(CAS#6224-91-5)
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29319090 |
| Hazard Class | 3 |
| Packing Group | II |
Introduction
Trimethylsilylpropyne is an organosilicon compound. Here's an introduction to its properties and uses:Quality:1. Appearance: colorless liquid4. Density: 0.745 g/mLUse:1. Trimethylsilylpropyne can be used as an important reagent in organic synthesis, especially in metal-catalyzed reactions.2. It can be used for the synthesis, polymerization and metapolymerization of olefins, such as the synthesis of polymers and polymer compounds.Method:Trimethylsiliconylpropyne can be prepared by:1. Trimethylchlorosilane is reacted with hydrogen chloride in the presence of a base.2. In the presence of trimethylchlorosilane and acetylene, the reaction is heated at high temperatures.Safety Information:1. Trimethylsiliconylpropynyl is a flammable liquid and should be kept away from fire and heat sources.2. Pay attention to avoid contact with skin and eyes during operation, and wear personal protective equipment.3. Store tightly sealed and away from oxidants during storage and use.4. In case of accidental leakage, ventilate the surrounding environment immediately and take appropriate protective measures to remove it.
Application
1-(Trimethylsilyl)prop-1-yne (Trimethyl(prop-1-yn-1-yl)silane, CAS 6224-91-5) is a colorless liquid terminal alkyne with a protective trimethylsilyl (TMS) group, serving as a versatile building block for organic synthesis. It is widely used as an alkynylating reagent in Sonogashira and other cross-coupling reactions to introduce alkyne moieties into complex molecular scaffolds. The TMS group enables orthogonal protection and can be cleaved under basic conditions to generate terminal alkynes for click chemistry, cycloadditions, and further functionalization. In medicinal chemistry, it is a valuable pharmaceutical intermediate for the synthesis of heterocyclic compounds, antiviral drugs, and anticancer agents. In materials science, it is used to prepare functional polymers, conjugated systems, and organosilicon materials. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 1-(Trimethylsilyl)prop-1-yne with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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