11-(tert-Butoxycarbonylamino)undecanoic acid(CAS#10436-25-6)

Introduction

Tert-butoxycarbonyl-11-aminoundecanoic acid (BOC-11-aminoundecanoic acid) is an organic compound. It is a white solid that is soluble in organic solvents such as ether or chloroform. BOC-11-aminoundecanoic acid has a variety of uses and is mainly used as a protecting group in organic synthesis. The tert-butoxycarbonyl group (BOC) is a commonly used protective group that protects the amino group from accidental reactions or side reactions during synthesis. The preparation method of BOC-11-aminoundecanoic acid is generally obtained by esterification reaction with aminoundecanoic acid. Tert-butyl tert-butyl ether carbonyl copper chloride (BOC-Cl) was added to the solution of aminoundecanoic acid, and the reaction was carried out under carbonate buffer conditions to obtain BOC-11-aminoundecanoate. Then, BOC-11-aminoundecanoic acid is obtained by alkaline hydrolysis. The safety information of BOC-11-aminoundecanoic acid has not been clearly reported. In general, appropriate personal protective equipment, such as lab gloves and protective glasses, should be worn when handling chemicals to prevent direct contact or inhalation. It should be kept in a cool, dry, well-ventilated place and away from fire and combustible substances. When using BOC-11-aminoundecanoic acid, proper handling methods and laboratory safety guidelines must be followed.

Application
11-(tert-Butoxycarbonylamino)undecanoic acid (Boc-11-aminoundecanoic acid, CAS 10436-25-6) is a long-chain ω-amino fatty acid with a Boc-protected terminal amine. It serves as a versatile building block for the synthesis of PEGylated linkers, antibody-drug conjugates (ADCs), and bioconjugates. The carboxylic acid group enables amide or ester bond formation, while the Boc group allows selective deprotection under mild acidic conditions. This compound is widely used in drug delivery systems to attach therapeutic agents to targeting moieties, improving pharmacokinetics and reducing off-target toxicity. It also finds applications in the preparation of self-assembled monolayers (SAMs), surface coatings, and hydrogel crosslinkers. In pharmaceutical R&D, it is utilized to synthesize long-chain aliphatic prodrugs, enzyme inhibitors, and fatty acid-modified peptides. Its high purity (≥98%) ensures reproducibility in complex conjugation chemistry. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.