D-Serine ethyl ester hydrochloride(CAS#104055-46-1)
Introduction
D-serine ethyl ester hydrochloride is an ethyl ester of D-serine in the form of the hydrochloride salt. The following is a description of its nature, use, preparation and safety information:
Nature:
D-serine ethyl ester hydrochloride is a white crystalline solid with good solubility. It is the esterification product of the reaction of D-serine with acetic anhydride, the solubility of which is enhanced in the hydrochloride form.
Use:
D-serine ethyl ester hydrochloride has important applications in chemical research and pharmaceutical fields. It can be used in the synthesis of biologically active molecules such as drugs and pharmaceutical intermediates. Serine ethyl ester itself is a common amino acid protecting group, which can be used in solid phase synthesis and biocatalytic reaction of amino acids. Serine also has important physiological functions in the human body, so its esterified form also has some potential in drug development.
Preparation Method:
A common method for preparing D-serine ethyl ester hydrochloride is to react D-serine with acetic anhydride under appropriate reaction conditions, followed by the addition of hydrochloric acid to obtain the product in the form of hydrochloride. Specific reaction conditions and procedures may vary depending on laboratory conditions and requirements.
Safety Information:
D-serine ethyl ester hydrochloride is usually relatively safe under correct handling and storage, but the following matters still need to be paid attention:
1. Appropriate personal protective measures shall be taken during preparation and operation, such as wearing laboratory protective glasses, gloves, laboratory clothes, etc.
2. serine ethyl ester hydrochloride has a certain corrosive, should avoid contact with the skin and eyes, such as accidental contact should immediately rinse with plenty of water, and seek medical help.
3. During storage and handling, avoid contact with flammable substances and strong oxidants to prevent the risk of fire and explosion.
4. Carefully read the product safety data sheet (MSDS) and relevant safety information provided by the supplier before use to ensure safe operation.
Application
D-Serine ethyl ester hydrochloride (CAS 104055-46-1) is a high-purity chiral amino acid derivative used as a versatile building block in pharmaceutical and peptide synthesis. As a key pharmaceutical intermediate, it facilitates the introduction of the D-serine moiety into drug candidates, enhancing metabolic stability and bioactivity, particularly in the development of CNS-active agents, antibiotics, and anticancer therapeutics. The ethyl ester group enables selective protection and deprotection strategies, while the hydrochloride salt improves water solubility and handling stability. This compound is extensively employed in custom chemical synthesis for the production of dipeptides, peptidomimetics, and enzyme inhibitors. It also serves as a chiral resolving agent and a reference standard for analytical method development. Xinchem offers custom synthesis and contract manufacturing of high-purity D-Serine ethyl ester hydrochloride with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
