5-Bromo-2-hydroxynicotinic acid(CAS#104612-36-4)

5-Bromo-2-hydroxynicotinic acid(CAS#104612-36-4)

Physical
Appearance: White powder
Density: 2.015g/cm³
Melting Point: 287°C
Boiling Point: 354.7ºC at 760mmHg
Flash Point: 287°C
Vapor pressure: 5.49e-06mmHg at 25°C
LogP：0.83560
PSA：70.16000
Chemical properties
It has the typical properties of carboxylic acid and phenolic hydroxyl group, and can undergo esterification reaction, acid-base neutralization reaction, etc. The bromine atom on its pyridine ring can undergo substitution reactions under certain conditions, such as reacting with nucleophiles and being replaced by other groups. The hydroxyl group in the molecule can form complexes with metal ions, etc. In addition, the acidity coefficient pKa of the substance is 2.09±0.201.
Fields of application
It is mainly used as a pharmaceutical intermediate, which can be used to synthesize a variety of biologically active compounds and drugs. For example, in the synthesis route of some new antimicrobial drugs, anti-inflammatory drugs or drugs for the treatment of cardiovascular diseases, they can be used as key starting materials or intermediates to introduce specific functional groups or construct specific structures of drug molecules through a series of chemical reactions to give drugs corresponding pharmacological activity.
Storage conditions
It should be stored in a cold and dry place, and it is usually recommended to store it at room temperature in an inert gas atmosphere to avoid contact with air, moisture, etc., to prevent it from deteriorating or degrading reactions

Application
5-Bromo-2-hydroxynicotinic acid is a functionalized pyridine derivative serving as a key pharmaceutical intermediate in drug discovery. Its unique structure, combining a bromine atom at the 5-position and a hydroxyl group at the 2-position of the nicotinic acid core, enables diverse transformations for constructing biologically active molecules. This heterocyclic building block is extensively utilized in the synthesis of antihypertensive agents, antiviral drugs, and antiblockamine medications. Due to its structural similarity to nicotinic acid, it is particularly valuable in developing therapeutics targeting neurological disorders, including cognitive dysfunction and addiction. The compound also acts as a ligand for nicotinic acetylcholine receptors in biochemical research, aiding studies on cellular signaling pathways. Furthermore, it demonstrates potential antioxidant properties for combating oxidative stress-related diseases and can be explored in agricultural chemistry for crop protection and material science for functional polymers and coatings. Its versatility in cross-coupling reactions (Suzuki, Sonogashira) and amide bond formation supports rapid structure-activity relationship studies in medicinal chemistry. Xinchem offers custom synthesis and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.