1H-Imidazole-1-sulfonyl azide hydrochloride（CAS# 952234-36-5)
Introduction
Azide hydrochloride is an organic compound with the chemical formula C3H4N6O2S • HCl. It is a white crystalline solid, soluble in water and organic solvents such as alcohol, ether, etc.
azo hydrochloride has a wide range of applications in organic synthesis. It can be used as a nitrogen source to react with electrophiles to produce the corresponding compounds. It is often used in the synthesis of alkynes, cycloaddition reactions, the synthesis of cyclic compounds.
The method for preparing the imidazole hydrochloride is generally to react with sulfonyl chloride, and then react the obtained imidazole sulfonyl chloride with ammonium chloride to obtain the product.
Pay attention to the safety information when using the hydrochloride. It is a highly explosive compound, should be away from fire, static and other sources of fire. Wear protective glasses, protective gloves and other personal protective equipment during operation, and operate in a well-ventilated place. Avoid contact with skin and inhalation of dust. During use, pay attention to sealing and preservation, and avoid contact with oxidants, ammonia or chlorinating agents, so as to avoid unsafe reactions. In the event of an accident, appropriate emergency measures should be taken immediately and professional help should be sought.
Application
1H-Imidazole-1-sulfonyl azide hydrochloride (CAS 952234-36-5) is a versatile organic azide salt widely utilized as a diazo transfer reagent in organic synthesis. It functions as a "diazo donor" for the conversion of primary amines into azides and for transforming activated methylene substrates into diazo compounds. The compound also plays a pivotal role in the synthesis of sulfonyl azides from primary sulfonamides. In medicinal chemistry and drug discovery, it is employed to create imidazole-based biologically active molecules and various organic functional materials. Its ability to undergo nucleophilic substitution reactions with amino-containing organic molecules enables the formation of corresponding diazonium compounds. As a stable and easy-to-handle crystalline salt, it serves as a crucial intermediate in the synthesis of 1,2,3-triazoles, bioactive compounds, and pharmaceutical building blocks. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 1H-Imidazole-1-sulfonyl azide hydrochloride with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
