2 6-Dichloro-4-iodopyridine（CAS# 98027-84-0)

2 6-Dichloro-4-iodopyridine（CAS# 98027-84-0) introduction

2,6-dichloro-4-iodopyridine is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:

Quality:
- Appearance: 2,6-Dichloro-4-iodopyridine is a white to yellowish crystalline powder.
- Stable at room temperature, but susceptible to light and moisture.
- It has certain solubility in solvents, such as methanol and methylene chloride.
- Toxic gases are released during combustion.

Use:
- 2,6-Dichloro-4-iodopyridine is an important organic intermediate that can be used in the synthesis of other compounds.

Method:
- 2,6-Dichloro-4-iodopyridine is usually obtained by the reaction of pyridine iodide and cuprous chloride in an appropriate solvent.
- The reaction requires the use of appropriate reaction conditions and catalysts, usually in an inert atmosphere.

Safety Information:
- 2,6-Dichloro-4-iodopyridine is an organic compound that is toxic and irritating.
- Wear appropriate precautions, such as protective eyewear and gloves, during handling and use.
- Avoid inhalation, contact with skin and eyes, and avoid swallowing.
- Avoid contact with substances such as oxidants and strong acids.
- Read and follow the relevant safety operation guidelines and operating procedures carefully before use. When used in a laboratory environment, the appropriate safety operating procedures should be observed.

Application
2,6-Dichloro-4-iodopyridine (CAS 98027-84-0) is a highly functionalized pyridine building block that features orthogonal halogen reactivity: a reactive iodine at the 4-position and two chlorines at the 2- and 6-positions. This unique substitution pattern enables stepwise, chemoselective transformations—the C–I bond undergoes preferential cross-coupling (Suzuki-Miyaura, Sonogashira) while the C–Cl bonds remain available for subsequent functionalization—making it indispensable for constructing diverse 2,4,6-trisubstituted pyridines.

In pharmaceutical R&D, this scaffold serves as a key intermediate for anti-cancer agents, antibiotics, anti-infective, and anti-inflammatory drugs. Its derivatives have shown antiviral activity by inhibiting viral protein-protein interactions (e.g., PA–PB1) critical for replication, as well as selective anticancer activity against specific cancer cell lines. It is also utilized in receptor interaction studies, including the synthesis of high-affinity ligands for human adenosine receptors.

In agrochemical research, it serves as a precursor for herbicides, fungicides, and pesticides. In materials science, its halogenated structure is explored for electronic materials, polymers, and coatings. As a versatile organic synthesis building block, it is also used in biochemical assays and as a sulfonylation reagent for drug discovery.

Xinchem offers high-purity 2,6-Dichloro-4-iodopyridine (≥98%)with flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing to support your pharmaceutical, agrochemical, and material science R&D. Contact us for a competitive quote and dependable global supply.