2-(BroMoMethyl)-5-(trifluoroMethyl)pyridine(CAS#1000773-62-5)

Introduction

2-Bromomethyl-5-(trifluoromethyl)pyridine is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:2-Bromomethyl-5-(trifluoromethyl)pyridine is a yellow to yellowish brown crystal. It is solid at room temperature and has the property of being insoluble in water.Use:2-Bromomethyl-5-(trifluoromethyl)pyridine is a chemical reagent that is mainly used in organic synthesis reactions, especially as a catalyst or intermediate.Method:The preparation method of 2-bromomethyl-5-(trifluoromethyl)pyridine is relatively complex. A commonly used preparation method is prepared by sulfonylation of pyridine and recombination of broken bonds. First, pyridine is reacted with sulfonylmethyl chloride to obtain 2-(pyridyl)-5-sulfonylmethylpyridine. Then, it is reduced with hydrogen and palladium catalysts to obtain 2-bromomethyl-5-(trifluoromethyl)pyridine.Safety Information:2-Bromomethyl-5-(trifluoromethyl)pyridine has a good safety profile and low toxicity under normal use conditions. Avoid inhaling its dust or gases. In case of accidental poisoning, seek medical attention immediately.

Application
2-(Bromomethyl)-5-(trifluoromethyl)pyridine (CAS 1000773-62-5) is a high-purity functionalized pyridine derivative containing a reactive bromomethyl group and an electron-withdrawing trifluoromethyl (CF₃) substituent. The bromomethyl moiety serves as an efficient alkylating agent for nucleophilic substitution reactions with amines, thiols, and alcohols, enabling rapid introduction of the fluorinated pyridine scaffold into drug candidates. The CF₃ group enhances metabolic stability, lipophilicity, and target binding affinity, making this building block invaluable in medicinal chemistry. It is widely used in the synthesis of potent kinase inhibitors (e.g., JAK, BTK, CDK inhibitors), antiviral agents, and CNS-active pharmaceutical ingredients. The rigid, electron-deficient pyridine core improves pharmacokinetic properties. This intermediate also supports agrochemical development (herbicides, fungicides) and the preparation of functional materials, ligands for catalysis, and fluorescent probes. High purity ensures reproducible results in high-throughput screening, structure-activity relationship (SAR) studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.