2-(Bromomethyl)-6-fluoropyridine(CAS#100202-78-6)
Introduction
2-(Bromomethyl)-6-fluoropyridine is an organic compound with the chemical formula C6H5BrFN. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-(Bromomethyl)-6-fluoropyridine is a colorless to pale yellow liquid.
-Solubility: It can be dissolved in some organic solvents, such as dimethyl sulfoxide (DMSO) and ethanol.
Use:
- 2-(Bromomethyl)-6-fluoropyridine is often used as an intermediate in organic synthesis. It can be used to synthesize various other organic compounds, such as drugs, pesticides and dyes.
Preparation Method: The preparation of
- 2-(Bromomethyl)-6-fluoropyridine can generally be achieved by the following steps:
1. react 6-fluoropyridine with methyl bromide to generate 2-(Bromomethyl)-6-fluoropyridine.
Safety Information:
- 2-(Bromomethyl)-6-fluoropyridine is a chemical that should be handled with care. Appropriate protective measures, such as wearing chemical goggles, gloves and protective clothing, are required during use.
-It should be used in a well-ventilated place, avoiding inhalation of its vapor or contact with skin and eyes.
-During storage and handling, it needs to be stored separately from oxidants and strong acids to avoid possible dangerous reactions.
Please note that the above information is for reference only. In practical applications, the exact safe operation guidelines and chemical laboratory guidelines should be followed.
Application
2-(Bromomethyl)-6-fluoropyridine is a reactive alkylating agent widely used in medicinal chemistry and drug discovery. The presence of a fluorine atom enhances metabolic stability and lipophilicity, while the bromomethyl group enables efficient nucleophilic substitution with amines, thiols, and alcohols. This building block serves as a key intermediate for the synthesis of kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, and CNS-targeted drugs. It is also employed in the preparation of pyridine-based ligands for catalysis and metal-organic frameworks. In agrochemical research, derivatives are used to develop herbicides and fungicides. Its rigid, electron-deficient pyridine core improves target binding affinity and selectivity. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
