4-Chloroisoquinoline(CAS#1532-91-8)
Introduction
4-chlorine isoquinoline, chemical formula C10H6ClN, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-choroisoquinoline is a colorless to pale yellow crystalline solid.
-Melting point: Its melting point is about 86-88 ° C.
-Solubility: It can be dissolved in some organic solvents, such as ethanol, benzene and dimethylformamide.
-Chemical properties: It has a certain electron affinity and can be used as an electron acceptor to participate in some electron transfer reactions.
Use:
- 4-Chloroisoquinoline is a commonly used organic synthesis intermediate, which is widely used in the preparation of other compounds.
-It can be used to synthesize various compounds such as dyes, ligands, catalysts and drugs.
Method:
-A common preparation method of 4-Chloroisoquinoline is obtained by heating and condensing 4-chloropyridine. The specific reaction conditions can be adjusted according to the specific situation.
Safety Information:
-4-chlorine isoquinoline is generally relatively safe under normal conditions of use, but it is still necessary to pay attention to its safe use and storage:
-Because it is an organic compound, care should be taken to avoid direct contact with the skin or inhalation of its vapor to prevent irritation and absorption.
-During operation and storage, seal the container from direct sunlight.
-For any chemical, you must follow correct operating procedures and safe laboratory practices, and pay attention to the use of personal protective equipment, such as laboratory gloves and glasses.
Please note that the use and operation involving chemicals must be carried out in accordance with relevant regulations and safety operation guidelines. It is strongly recommended to consult the relevant literature and consult a professional before use.
Application
4-Chloroisoquinoline (CAS 1532-91-8) is a versatile heterocyclic building block featuring a chlorine atom at the 4-position of the isoquinoline core. It is widely employed in medicinal chemistry and drug discovery for the synthesis of bioactive molecules including kinase inhibitors, anticancer agents, and antimicrobial compounds. The reactive chlorine enables selective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing rapid introduction of diverse aryl, heteroaryl, or alkyl substituents for structure-activity relationship (SAR) studies. This scaffold serves as a key intermediate in the development of potent inhibitors targeting various biological pathways such as PI3K, DNA topoisomerases, and GPCRs. It is also utilized in the synthesis of fluorescent probes, agrochemicals, and functional materials. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-chloroisoquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
