1,4-Dichloroisoquinoline(CAS#15298-58-5)
Introduction
1,4-dichloroisoquinoline is an organic compound with the chemical formula C9H5Cl2N. The following is a description of its nature, use, preparation and safety information:
Nature:
1,4-dichloroisoquinoline is a colorless to pale yellow solid with a special odor. It has moderate solubility and is soluble in organic solvents such as alcohols, ethers and benzene. This compound decomposes at high temperatures and is unstable to light and air.
Use:
1,4-dichloroisoquinoline has a wide range of uses in the laboratory and industry. It can be used as an important intermediate in organic synthesis. This compound plays an important role in the preparation of antibiotics, pesticides, dyes and other organic compounds. In addition, it can also be used to prepare certain metal complexes of similar structure.
Method:
1,4-dichloroisoquinoline can be obtained by chlorinating isoquinoline chloride. This reaction may use chlorine or stannous chloride as the chlorinating agent. The reaction is usually carried out in a suitable solvent and requires a suitable temperature and reaction time. After the reaction, the product can be purified by concentration and crystallization.
Safety Information:
1,4-dichloroisoquinoline is an organic compound, so it should be handled with caution. It is an irritant substance and may cause irritation to the eyes, skin and respiratory system. During use or operation, appropriate protective measures should be taken, such as wearing protective glasses, gloves and protective clothing. In addition, this compound is also toxic and should be kept away from children and animals.
Application
1,4-Dichloroisoquinoline (CAS 15298-58-5) is a versatile dihalogenated heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. The chlorine atoms at the 1- and 4-positions allow sequential, site-selective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), enabling rapid construction of diverse polysubstituted isoquinoline libraries for structure-activity relationship (SAR) studies. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and neurological disorders, as well as modulators of GPCRs, DNA topoisomerases, and other biological targets. It is also utilized in the development of antiviral, antimicrobial, and anti-inflammatory agents, fluorescent probes for bioimaging, and agrochemicals. Its rigid, planar isoquinoline core enhances target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 1,4-dichloroisoquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
