Quinoline-7-carboxylic acid(CAS#1078-30-4)
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29334900 |
Introduction
7-Quinolinic acid, also known as 7-quinolinic acid, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 7-quinolinecarboxylic acid is white crystal or crystalline powder.
-Solubility: It is easily soluble in water and organic solvents such as ethanol and chloroform.
-Chemical properties: 7-quinolinecarboxylic acid is acidic and can react with alkali to generate the corresponding salt.
Use:
-Drug synthesis: 7-quinolinecarboxylic acid is an important intermediate, widely used in the pharmaceutical industry. It can be used to synthesize drugs with antiviral, antibacterial, anticancer and other activities.
-Pesticide synthesis: This compound can also be used to synthesize certain pesticides, such as pesticides and herbicides.
-Chemical research: 7-quinolinecarboxylic acid can be used in organic synthesis reactions and catalyst preparation and other fields.
Preparation Method:
- 7-quinolinecarboxylic acid can be synthesized by benzopyriquine reaction. The specific steps include the reaction of benzopyriquine with carbon monoxide to generate carbonyl compounds, and then carboxylation reaction to obtain 7-quinolinecarboxylic acid.
Safety Information:
-7-Quinolinic acid is relatively safe to the human body and the environment under normal conditions of use, but the following points still need to be noted:
-Contact: Avoid direct skin contact and wear gloves for handling.
-Inhalation: Avoid inhaling dust or aerosols. If inhalation occurs, please quickly move to a well-ventilated place.
-Eye contact: In case of eye splash, rinse immediately with plenty of water and seek medical advice.
-Storage: It should be kept in a dry, cool place, away from combustibles and oxidants.
-Waste Disposal: Disposal or recycling in accordance with local regulations.
Application
Quinoline-7-carboxylic acid (CAS 1078-30-4) is a versatile heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. Its rigid quinoline core and reactive carboxylic acid group enable the synthesis of diverse bioactive molecules, including potent kinase inhibitors targeting cancer (e.g., EGFR, PI3K, and CDK), antimicrobial agents, and antimalarial drugs. The carboxylate handle allows facile amide bond formation with amines, facilitating rapid structure-activity relationship (SAR) studies for drug discovery. This scaffold also serves as a key intermediate in the preparation of fluorescent probes, metal-organic frameworks (MOFs), and agrochemicals. As a pharmaceutical intermediate, it is employed in the synthesis of anti-inflammatory and antiviral compounds. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity quinoline-7-carboxylic acid with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
