2-(4-Fluorophenyl)-thiophene(CAS#58861-48-6)
Introduction
2-(4-fluorophenyl)thiophene is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:1. Properties:- Appearance: 2-(4-fluorophenyl)thiophene is a colorless or light yellow solid. - Solubility: It dissolves in some organic solvents (e.g., dimethyl sulfoxide, acetonitrile). It has less solubility in water. 2. Uses: - 2-(4-fluorophenyl)thiophene is often used as one of the components of optoelectronic materials and organic electronic devices. - It can be used to prepare organic light-emitting diodes (OLEDs), organic solar cells (OPVs) and sensors, etc. 3. Preparation method: The preparation method of 2-(4-fluorophenyl)thiophene can be obtained by the reaction of sodium salt of thiophene and 4-fluorophenylboronic acid under alkaline conditions. The specific steps are as follows:- Reaction of thiophene and sodium 4-fluorophenylborate under alkaline conditions. - After the reaction is completed, 2-(4-fluorophenyl)thiophene can be obtained by hydrolysis under acidic conditions. 4. Safety Information:- 2-(4-fluorophenyl)thiophene is relatively safe for humans under normal operating conditions- Avoid inhaling dust or solvent vapors, and wear appropriate respiratory protective equipment. - Avoid contact with skin and eyes, rinse immediately with plenty of water and seek medical advice. - When storing, it should be sealed and kept away from fire and oxidants.
Application
2-(4-Fluorophenyl)thiophene (CAS 58861-48-6) is a key heteroaromatic intermediate featuring a 4-fluorophenyl group attached to a thiophene ring. As a premium pharmaceutical building block, its primary commercial application is as a critical, non-substitutable intermediate in the synthesis of Canagliflozin, a blockbuster sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for type 2 diabetes mellitus. The strategic para-fluorine substituent is essential for metabolic stability, target binding, and bioavailability of the API, and this fluorinated scaffold is also employed in the preparation of p38α MAPK inhibitors for inflammatory conditions, in developing novel antiviral and antidepressant agents, and as an advanced key intermediate for selective human estrogen receptor partial agonists (ShERPAs). Its conjugated structure and electron-withdrawing fluorine atom lower the LUMO level, enabling its use as an organic electronic material, particularly for n-channel organic field-effect transistors (OFETs). Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
