2-Bromothiophene(CAS#1003-09-4)
| Risk Codes | R10 - Flammable R25 - Toxic if swallowed R41 - Risk of serious damage to eyes R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24 - R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S16 - Keep away from sources of ignition. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2929 6.1/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8 |
| TSCA | T |
| HS Code | 29349990 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | II |
Introduction
2-Bromothiophene is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 2-bromothiophene: Properties:- 2-bromothiophene is a colorless to light yellow solid. - 2-Bromothiophene is soluble in solvents and stable in air. - It has a strong odor. Uses: -2-bromothiophene is an important intermediate in organic synthesis and is widely used in the preparation of other compounds. - It is used in the production of dyes, fluorescent dyes, photosensitive materials, etc. - 2-Bromothiophene is also used in the field of organic solar cells. Method: - 2-bromothiophene can be prepared by reacting 2,5-dimethylthiophene with bromine under alkaline conditions. This reaction can be carried out in solvents, which are commonly used in alcohols, ethers, and aromatics. - During the preparation process, attention must be paid to safe handling measures because of the hazardous substance bromine. Safety Information:- 2-Bromothiophene is an organic compound, which is relatively stable under general conditions. - It is irritating and may cause irritation when it comes into contact with the skin and eyes. - Wear protective gloves and glasses when using, and ensure that the operation is carried out in a well-ventilated area. - Avoid contact with strong oxidants, strong acids or strong bases during storage and handling to avoid dangerous reactions. - If inhalation or accidental ingestion occurs, seek medical attention promptly.
Application
2-Bromothiophene is a versatile heteroaryl halide widely used as a building block in organic synthesis, medicinal chemistry, and materials science. It serves as a key pharmaceutical intermediate for the synthesis of various bioactive compounds, including antiviral, anticancer, anti-inflammatory, and antimicrobial agents. The bromine atom at the 2-position enables efficient palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Stille, Negishi, and Buchwald-Hartwig couplings, allowing rapid introduction of the thiophene ring into complex drug-like scaffolds. In agrochemical research, 2-bromothiophene is used to prepare herbicides, fungicides, and insecticides. It is also a precursor for conducting polymers, organic semiconductors, and light-emitting diodes (OLEDs) due to its electron-rich and conjugated structure. Its high purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of high-purity 2-bromothiophene with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
