2-Fluorophenol(CAS#367-12-4)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R10 - Flammable R63 - Possible risk of harm to the unborn child R43 - May cause sensitization by skin contact R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R45 - May cause cancer R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S24/25 - Avoid contact with skin and eyes. S23 - Do not breathe vapour. S53 - Avoid exposure - obtain special instructions before use. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | SL4530000 |
| TSCA | T |
| HS Code | 29081000 |
| Hazard Note | Flammable/Corrosive |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2-Fluorophenol is an organic compound. The following is an introduction to some of the properties, uses, preparation methods and safety information of 2-fluorophenol:- Properties:- Appearance: 2-fluorophenol is a colorless liquid. - Sense of smell: has a special phenolic odor. - Solubility: Soluble in organic solvents such as ethanol, ether and methylene chloride. Uses:- Biological Sciences: Can be used as biological reagents, enzyme catalysts, and research tools. Preparation method: - The preparation method of 2-fluorophenol can be achieved by introducing fluorine atoms on the phenol molecule. 2-fluorophenol is usually synthesized by using fluorine gas in a phenol solution or by adding phenol to the reaction by fluorinating reagents. Safety Information:- To humans: 2-fluorophenol can enter the human body through inhalation, ingestion, and skin contact. It can cause irritation to the respiratory system, skin, and eyes. Long-term exposure may have damaging effects on the liver and kidneys. Appropriate safety measures should be taken when using 2-fluorophenol and good ventilation conditions should be ensured. - Environmental impact: 2-fluorophenol is toxic to aquatic organisms and the environment, and may have a negative impact on aquatic ecosystems. Environmental protection regulations should be observed when handling and disposing of 2-fluorophenol.
Application
2-Fluorophenol (CAS 367-12-4) is a versatile fluorinated aromatic building block widely used in pharmaceutical, agrochemical, and material science research. In medicinal chemistry, it serves as a key intermediate for the synthesis of non‑steroidal anti‑inflammatory drugs (NSAIDs) such as flurbiprofen, as well as antiviral, analgesic, and antipsychotic agents. The strategic ortho‑fluorine substitution enhances metabolic stability, lipophilicity, and target binding affinity. In agrochemical development, 2‑fluorophenol is a precursor for selective herbicides, fungicides, and insecticides with improved environmental profiles. Its phenolic OH enables etherification, esterification, and cross‑coupling reactions, including Suzuki‑Miyaura and Buchwald‑Hartwig couplings, allowing rapid construction of complex molecular scaffolds. Additionally, it is employed in the production of liquid crystal display (LCD) monomers, specialty polymers, and functional coatings. High purity ensures reproducible results in high‑throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity 2‑fluorophenol to meet your research and production needs. Contact us for a competitive quote and reliable global supply.
