2-Fluorotoluene(CAS#95-52-3)
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2388 3/PG 2 |
| WGK Germany | 3 |
| RTECS | XT2579000 |
| TSCA | Yes |
| HS Code | 29036990 |
| Hazard Note | Flammable/Irritant |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
Introduction
2-Fluorotoluene o-Fluorotoluene 1-Fluoro-2-methylbenzene | CAS 95 52 3
One Line Sourcing Position
High purity 2-Fluorotoluene for pharmaceutical intermediates, agrochemical synthesis, and specialty organic chemistry applications.
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Specification
| Parameter | Specification |
|---|---|
| Purity by GC | 99.0 percent minimum, typical batch 99.0 to 99.5 percent |
| Appearance | Colorless transparent liquid |
| Molecular Formula | C7H7F |
| Molecular Weight | 110.13 g per mol |
| Melting Point | minus 62 degrees Celsius |
| Boiling Point | 113 to 114 degrees Celsius |
| Density at 25 deg C | 1.001 g per mL |
| Refractive Index n20/D | 1.473 |
| Vapor Pressure | 21 mmHg at 20 degrees Celsius |
| Vapor Density | 3.8 (vs air) |
| Flash Point | 8 degrees Celsius (46.4 degrees Fahrenheit) |
| Solubility | Miscible with ethanol, diethyl ether, acetone, benzene; not miscible with water |
| Storage Temperature | Room temperature in a cool and dark place below 15 degrees Celsius |
| Stock Status | In Stock in US warehouse and China hub |
Available Quantity and Lead Time
Regular supply: 1 kg to 30 metric tons per shipment
Lead time: 2 to 5 days for standard packaging; bulk orders require 7 to 10 days
Document Support
COA SDS HPLC chromatogram NMR spectrum Mass spectrum MS available upon request
Application
2-Fluorotoluene is a fluorinated aromatic compound valued for its unique reactivity and stability. The presence of the fluorine atom enhances the reactivity of the aromatic ring, making it a valuable precursor for various chemical transformations.
In the pharmaceutical industry, 2-fluorotoluene is widely utilized as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and fluorinated drugs. The fluorine substitution can significantly impact the pharmacokinetics of resulting drugs, enhancing their efficacy and therapeutic profile. It serves as a building block for the production of complex molecules across pharmaceutical research and development.
In agrochemical manufacturing, 2-fluorotoluene is employed as an intermediate for the synthesis of pesticides, herbicides, and other crop protection agents. It is also used in the production of diazo compounds and analytical reagents.
In specialty chemical synthesis, 2-fluorotoluene finds applications in the manufacture of coatings, dyes, and other fine chemicals. It is widely employed in organic synthesis as a precursor for various chemical transformations. The compound is also applicable in coupling reactions, drug molecule modification, and functional material synthesis. Additionally, it serves as a valuable research tool for exploring new chemical entities in drug discovery and development.
Custom Synthesis Support
We offer custom synthesis for 2-fluorotoluene derivatives including substituted analogs, isotopically labeled versions, and higher purity grades (99.5 percent and above). Custom packaging under inert atmosphere is available. Share your technical datasheet for feasibility review.
Packaging and Shipping
Available in 500 mL, 1 L, 5 L, 20 L, 200 L steel drums or IBC totes. Custom packaging such as amber glass bottles with PTFE lined caps under inert atmosphere is supported. Fastest dispatch within 7 days after order confirmation.
2-Fluorotoluene is a highly flammable liquid. UN 2388, Class 3, Packing Group II. Proper shipping name: FLUOROTOLUENES. Store in a cool, well ventilated area away from heat, sparks, and open flames. Keep container tightly sealed and store away from strong oxidizing agents and strong reducing agents. Storage temperature should not exceed 30 degrees Celsius. Keep container tightly sealed and store in a cool, dry condition in a well ventilated place.
Why XinChem
XinChem provides 2-fluorotoluene with strict control of purity and impurity profile for US customers. Our ISO 9001 certified facility monitors every batch by GC and density analysis, ensuring consistent quality for pharmaceutical, agrochemical, and specialty synthesis applications. We maintain a buffer stock in US warehouses for emergency deliveries within 48 hours. Each order includes a full documentation package: COA, SDS, and chromatograms accessible through our online portal. Our technical support team assists with handling precautions, stability under storage, and regulatory compliance including TSCA, EINECS (202-428-5), and REACH registration. For contract customers, we offer quarterly price locks and consignment inventory to reduce supply chain risk. Trusted by numerous pharmaceutical, agrochemical, and specialty chemical companies in North America. We also provide free sample evaluation for qualified R&D projects and a price match guarantee against any valid competitor quote for equivalent quality. All shipments include clear handling instructions and appropriate hazard communication to ensure safety throughout the supply chain.
FAQ
Q1 How should 2-fluorotoluene be stored safely?
A Store in a cool, well ventilated area away from heat, sparks, and open flames. Keep container tightly sealed and store away from strong oxidizing agents and strong reducing agents. Storage temperature should not exceed 30 degrees Celsius. Shelf life is 24 months under recommended conditions.
Q2 What purity grades do you supply?
A Standard grade is 99.0 percent minimum by GC. We also supply 99.5 percent grade for pharmaceutical and analytical reference applications upon request.
Q3 Is 2-fluorotoluene soluble in water?
A No, it is not miscible with water. It is soluble in ethanol, ether, acetone, benzene, and most organic solvents.
Q4 Do you provide sample quantities for method development?
A Yes, free samples are available for qualified US companies. Shipping fee applies for small quantities.
Q5 What are the main applications of 2-fluorotoluene?
A Primary applications include: (1) pharmaceutical intermediate for APIs and fluorinated drugs; (2) agrochemical intermediate for pesticides and herbicides; (3) building block for organic synthesis; (4) precursor for diazo compounds and analytical reagents; and (5) intermediate for coatings, dyes, and specialty chemicals.
Q6 What safety precautions are required when handling 2-fluorotoluene?
A 2-Fluorotoluene is highly flammable (H225). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It is harmful to aquatic life (H402). Use in a fume hood with full PPE including chemical resistant gloves, safety goggles, and protective clothing. Keep away from heat, sparks, open flames, and other ignition sources. Use explosion-proof equipment and non-sparking tools. In case of contact with eyes, rinse cautiously with water for several minutes.


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