2-Bromo-4,5,6-trifluoroaniline(CAS#122375-82-0)

Introduction

2-Bromo-4,5,6-trifluoroaniline is an organic compound. The following is an introduction to the properties, uses, preparation methods, and safety information of this compound.Quality:- Appearance: 2-Bromo-4,5,6-trifluoroaniline is a white crystalline solid.- Solubility: It can be dissolved in organic solvents (such as benzene, ethanol, dimethylformamide, etc.), but less solubility in water.Use:Method:- The preparation method of 2-bromo-4,5,6-trifluoroaniline is usually obtained by halogenation. One of the commonly used methods is to react 4,5,6-trifluoro-2-nitrobenzene with permanganate sulfite to obtain 2-bromo-4,5,6-trifluoroaniline.Safety Information:- 2-Bromo-4,5,6-trifluoroaniline is an organohalide and has certain toxicity- Avoid contact with skin and eyes, and wear appropriate protective gear when using.- Avoid inhaling aerosols or dust, and maintain a well-ventilated working environment.- Store away from fire and combustibles.

Application
2-Bromo-4,5,6-trifluoroaniline (CAS 122375-82-0) is a high‑purity, multihalogenated aniline used as a versatile pharmaceutical intermediate and agrochemical building block. Its dense pattern of three fluorine atoms strongly withdraws electron density, while the bromine provides a selective cross‑coupling handle (Suzuki‑Miyaura, Buchwald‑Hartwig, Sonogashira) and the primary amine supports amide, urea and heterocycle formation. This scaffold is a key precursor for fluoroquinolone antibiotics (e.g., lomefloxacin, norfloxacin), potentiating antimicrobial activity and metabolic stability. In oncology, it enables the synthesis of kinase inhibitors and antitumor small‑molecule candidates. The trifluorinated aromatic core improves lipophilicity and bioavailability. In crop protection, the compound serves as an intermediate for herbicides, fungicides and insecticides, where the fluorine substituents enhance environmental persistence and biological efficacy. It is also employed as a monomer for functional polymers, liquid crystal displays (LCDs), organic light‑emitting diodes (OLEDs) and specialty electronic materials. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity 2-Bromo-4,5,6-trifluoroaniline with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.