2-Bromo-4,6-difluoroaniline(CAS#444-14-4)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S25 - Avoid contact with eyes. |
| UN IDs | UN 1325 4.1/PG 2 |
| WGK Germany | 3 |
| HS Code | 29214200 |
| Hazard Note | Irritant |
| Hazard Class | 9 |
| Packing Group | III |
Introduction
2-Bromo-4,6-difluoroaniline is an organic compound. Its chemical formula is C6H3BrF2N. The following are some of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 2-Bromo-4,6-difluoroaniline is a colorless to pale yellow solid.
-Melting point: about 79-80 ℃.
-Boiling point: about 281 ℃.
-Solubility: It can be dissolved in some organic solvents, such as alcohols, ethers and organic ketones.
Use:
- 2-Bromo-4,6-difluoroaniline is commonly used as an intermediate in organic synthesis. It can be used to synthesize other compounds, such as fluorescent dyes and pesticides.
-The difluorophenyl and bromine groups of the compound can provide reactivity, making it suitable for participating in many substitution reactions.
Preparation Method:
- 2-Bromo-4,6-difluoroaniline can be synthesized by introducing bromine atoms into 4,6-difluoroaniline. A common method of synthesis is by introducing Br2 into the reaction with the addition of a suitable catalyst.
-The process of synthesizing this compound is dangerous, please follow the laboratory safety operation specifications.
Safety Information:
- 2-Bromo-4,6-difluoroaniline is an organic compound and should be treated with caution. It may cause irritation to the skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment such as lab glasses, gloves and lab coats during operation.
-During handling and storage, avoid contact with oxidants or strong acids to avoid possible reactions or dangers.
-Comply with local and national safety standards and regulations during use or disposal. If used or handled incorrectly, it may cause harm to the human body and the environment.
Application
2-Bromo-4,6-difluoroaniline is a versatile halogenated aniline building block used as a key intermediate in medicinal chemistry and pharmaceutical R&D. The C-2 bromine enables selective cross-coupling reactions to construct biaryl-based scaffolds for kinase inhibitors. In oncology research, it is instrumental in developing fluorinated active anticancer agents. In crop protection, this precursor enables the synthesis of herbicidal and fungicidal compounds. Emerging applications include OLED material precursors and specialty polymers. Its 4,6-difluoro pattern enhances metabolic stability, bioavailability, and target binding affinity. High purity ensures reproducible results for SAR studies, high-throughput screening, and GMP scale-up. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this advanced intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
