2,4-Difluorophenol(CAS#367-27-1)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R34 - Causes burns R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. |
| UN IDs | 1992 |
| WGK Germany | 3 |
| HS Code | 29081000 |
| Hazard Note | Harmful |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2,4-Difluorophenol is an organic compound. Here is some information about its properties, uses, manufacturing methods, and safety:Quality:- 2,4-Difluorophenol is a colorless crystalline solid that is soluble at room temperature in organic solvents such as methanol, ethanol, and methylene chloride.- It is an organophenolic compound that has phenolic characteristics, including a benzene ring with a hydroxyl group.- 2,4-Difluorophenol has some toxicity.Use:- 2,4-Difluorophenol can be used as an intermediate in fungicides and insecticides.- It is widely used in agriculture to control fungal and insect infections on fruit trees, vegetables, and other crops.- It can also be used for the preservative and anti-mildew treatment of tobacco.Method:- 2,4-Difluorophenol can be obtained by the reaction of phenol with hydrofluoric acid.- Initial reactions usually need to be carried out under acidic conditions.Safety Information:- 2,4-difluorophenol has certain toxicity and may be harmful to human health.- May cause irritation of the eyes, skin, and respiratory tract upon contact, inhalation, or overdose.- Prolonged or frequent exposure may cause damage to the central nervous system and kidneys.- Wear appropriate personal protective equipment such as gloves, goggles, and protective clothing when using.- During storage and handling, relevant safety guidelines and regulations should be followed.
Application
2,4-Difluorophenol (CAS 367-27-1) is a high-purity dihalogenated phenolic building block, valued as a versatile organic intermediate and specialty fine chemical across multiple industries. In the pharmaceutical industry, it serves as a key precursor for the synthesis of active pharmaceutical ingredients (APIs) including anti-cancer (voriconazole), anti-inflammatory, analgesic, and antifungal drugs. In agrochemical R&D, this fluorinated intermediate is a core building block for highly active herbicides (fluazifop-P-butyl, clodinafop-propargyl), insecticides, and plant growth regulators. It is also used to produce liquid crystal display (LCD) monomers, specialty polymers, dyes, and rubber/plastic additives. The hydroxyl group enables versatile derivatization (ethers, esters), while the fluorine atoms improve metabolic stability and bioactivity. Xinchem offers high-purity 2,4-Difluorophenol with flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing for global pharmaceutical and agrochemical markets, scaled from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.
