2,4-Difluoroaniline(CAS#367-25-9)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2941 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | BX3680000 |
| FLUKA BRAND F CODES | 8-9-23 |
| TSCA | T |
| HS Code | 29214210 |
| Hazard Note | Toxic |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
2,4-Difluoroaniline is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:2,4-Difluoroaniline is a colorless to pale yellow crystal with a peculiar odor. It is soluble in water and can also be soluble in most organic solvents.Uses: In chemical synthesis, it can be used as a derivative of amides, amide chain extenders and aromatic amines for the introduction of aniline groups in the synthesis process.Method:The preparation method of 2,4-difluoroaniline can be achieved by the reduction of p-fluorobenzene. A common method is to react fluorobenzene with sodium nitrite under acidic conditions to produce nitrosobenzene, which is then reduced to 2,4-difluoroaniline using a reducing agent such as iron powder.Safety Information:2,4-Difluoroaniline has certain toxicity under certain conditions. It is irritating and can cause damage to the eyes, skin, respiratory tract and digestive system. Appropriate personal protective equipment such as gloves and protective eyewear should be worn when using and handling this compound. It needs to be operated in a well-ventilated environment to avoid inhaling its vapors or coming into contact with its solutions.
Application
2,4-Difluoroaniline is a high-purity fluorinated aromatic amine serving as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty materials. In drug discovery, it is widely used to construct fluoroquinolone antibiotics (e.g., ciprofloxacin, norfloxacin), anticancer agents, and antifungal compounds, where the electron-withdrawing fluorine atoms enhance metabolic stability and bioavailability. As an agrochemical building block, it enables the production of selective herbicides, insecticides, and fungicides with improved crop protection efficacy. The compound also finds application in the synthesis of azo dyes, liquid crystal display (LCD) monomers, and high-performance polymers. Its reactive amine group allows facile derivatization via amidation, diazotization, and cross-coupling reactions for rapid structure-activity relationship (SAR) studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2,4-difluoroaniline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.




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