2,2,2-Trifluoroacetyl chloride(CAS#354-32-5)

Introduction

Trifluoroacetyl chloride is a colorless liquid with a strong pungent odor at room temperature. It is a highly reactive compound that reacts with moisture in water and air to form toxic gases. Trifluoroacetyl chloride is soluble in organic solvents such as acetone and ethanol. Trifluoroacetyl chloride is mainly used for acylation reactions in organic synthesis. It can be used as an acylation reagent to convert carboxylic acids into esters and generate acyl chloride. Trifluoroacetyl chloride can also be used as an acylation reagent, dehydrating agent, and reagent intermediate. One way to prepare trifluoroacetyl chloride is through the reaction of trifluoroacetic acid and thionyl chloride. This reaction is usually carried out at low temperatures and uses acids or oxidants as catalysts. Avoid direct contact with skin, eyes, and respiratory tract. During operation, appropriate protective measures such as wearing glasses, protective gloves and respiratory protective equipment need to be selected. It should work in a well-ventilated area to avoid its vapor accumulation. In the event of an accidental leak, it should be removed quickly and disposed of safely. It is important to use and store trifluoroacetyl chloride properly and to follow the handling and safe operating protocols of the relevant chemicals.

Application
2,2,2-Trifluoroacetyl chloride (CAS 354-32-5) is a highly reactive fluorinated acyl chloride widely used as a versatile building block in pharmaceutical, agrochemical, and material chemistry. It serves as a key intermediate for introducing the trifluoroacetyl group into target molecules via acylation reactions. In drug discovery, it is essential for synthesizing trifluoromethylated drug candidates, including antiviral agents (e.g., nucleoside analogs), anti-inflammatory compounds, and central nervous system (CNS) therapeutics. The CF₃CO moiety enhances metabolic stability, lipophilicity, and bioavailability. In peptide chemistry, it acts as a protecting reagent for amino groups and as a coupling agent. In agrochemical research, trifluoroacetyl chloride is used to prepare herbicides, fungicides, and insecticides with improved field efficacy. It also finds applications in the production of fluorinated polymers, specialty solvents, and electronic chemicals. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity trifluoroacetyl chloride, supporting flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.