2,4-Difluorobenzotrifluoride(CAS#64248-61-9)
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 1993 |
Introduction
2,4-Difluorobenzotrifluoride, also known as 2,4-Difluorobenzotrifluoride, is an organic compound. Its chemical formula is C7H3F5 and its molecular weight is 178.09g/mol.
Nature:
2,4-Difluorobenzotrifluoride is a colorless liquid with a lower boiling point and a higher melting point. It is insoluble in water at room temperature, but soluble in organic solvents such as ethanol and benzene. It has a strong volatile and pungent odor.
Use:
2,4-Difluorobenzotrifluoride is widely used in industrial production. It is commonly used as an organic solvent, surfactant and catalyst. It can also be used as an additive for special coatings, plastics and rubber, with anti-corrosion and temperature resistance.
Preparation Method:
2,4-Difluorobenzotrifluoride can be prepared by different synthetic methods. A common method is by a substitution reaction of trifluorotoluene with hydrofluoric anhydride to give 2,4-Difluorobenzotrifluoride.
Safety Information:
2,4-Difluorobenzotrifluoride is relatively safe under normal use conditions, but it is still necessary to pay attention to the protection requirements during operation. It has a pungent odor and should avoid direct contact with the skin and eyes. During operation, wear appropriate personal protective equipment, such as protective gloves, goggles and protective clothing. In addition, you must ensure that you operate in a well-ventilated environment and avoid inhaling its vapors. During storage and handling, contact with strong oxidants and high temperatures should be avoided to prevent the risk of fire and explosion.
Please note that when using any chemical substances, please follow the relevant safety procedures, and carefully read and follow the safety data sheet provided with the product.
Application
2,4-Difluorobenzotrifluoride (CAS 64248-61-9) is a high-purity fluorinated aromatic compound widely used as a versatile building block in pharmaceutical and agrochemical research. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the two fluorine atoms provide strong electron-withdrawing effects, enabling regioselective nucleophilic aromatic substitution and cross-coupling reactions. This intermediate serves as a key precursor for the synthesis of fluoroquinolone antibiotics (e.g., ciprofloxacin, norfloxacin), antifungal agents, and anticancer drug candidates. In crop protection, it is utilized to develop selective herbicides, fungicides, and insecticides with improved environmental safety and bioavailability. Additionally, this compound finds applications in the production of liquid crystal materials, fluorinated polymers, and specialty dyes. Its high purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 2,4-difluorobenzotrifluoride with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
