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2,4-Difluorobenzylalcohol(CAS#56456-47-4)

Chemical Property:

Molecular Formula C7H6F2O
Molar Mass 144.12
Density 1.29g/mLat 25°C(lit.)
Boling Point 52 °C
Flash Point 194°F
Vapor Presure 0.279mmHg at 25°C
Appearance clear liquid
Specific Gravity 1.290
Color Colorless to Light orange to Yellow
BRN 2501944
pKa 13.82±0.10(Predicted)
Storage Condition Sealed in dry,Room Temperature
Refractive Index n20/D 1.487(lit.)
MDL MFCD00009983
Physical and Chemical Properties The flash point is 90 ° C., the refractive index is 1.4870, and the specific gravity is 1.290.

Product Detail

Product Tags

Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 3
HS Code 29062990
Hazard Class IRRITANT
Packing Group III

 

Introduction

2,4-Difluorobenzyl alcohol is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:2,4-Difluorobenzyl alcohol is a colorless liquid. It has a strong aroma and is soluble in most organic solvents such as ether, chloroform and alcohols.Use:2,4-Difluorobenzyl alcohol is often used as an intermediate in organic synthesis. It can also be used as a solvent, or in the preparation of high-performance resins, surfactants, etc.Method:The preparation of 2,4-difluorobenzyl alcohol is usually achieved by fluorination. A common preparation method is to use benzyl alcohol as a starting substance, which undergoes a fluorination reaction to introduce fluorine atoms. Commonly used fluorinating agents include hydrogen fluoride, sodium trifluoromethanesulfonate, etc.Safety Information:2,4-Difluorobenzyl alcohol has an irritating effect on the skin and eyes of the human body under general operating conditions. Rinse immediately with clean water upon contact and follow proper safety operating procedures. It may also have some toxicity and should be operated in a well-ventilated area and avoided from inhalation and ingestion. When using or storing, the relevant safety guidelines and precautions need to be followed.

Application
2,4-Difluorobenzyl alcohol is a high-purity fluorinated aromatic intermediate widely used in pharmaceutical, agrochemical, and material science R&D. Its two fluorine atoms enhance metabolic stability, lipophilicity, and bioavailability of drug candidates. The primary alcohol group enables oxidation to aldehyde or carboxylic acid, esterification, and ether formation, facilitating rapid structure-activity relationship (SAR) studies. This versatile building block serves as a key precursor for synthesizing CNS-active agents (antidepressants, antipsychotics), kinase inhibitors, anti-inflammatory APIs, and antiviral drugs. In agrochemistry, it is utilized to develop selective herbicides, fungicides, and insecticides with improved target selectivity and environmental safety. Additionally, it finds applications in liquid crystal display materials, specialty polymers, and fluorinated fine chemicals. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2,4-difluorobenzyl alcohol with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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