2,4-Difluorobenzylalcohol(CAS#56456-47-4)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29062990 |
| Hazard Class | IRRITANT |
| Packing Group | III |
Introduction
2,4-Difluorobenzyl alcohol is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:2,4-Difluorobenzyl alcohol is a colorless liquid. It has a strong aroma and is soluble in most organic solvents such as ether, chloroform and alcohols.Use:2,4-Difluorobenzyl alcohol is often used as an intermediate in organic synthesis. It can also be used as a solvent, or in the preparation of high-performance resins, surfactants, etc.Method:The preparation of 2,4-difluorobenzyl alcohol is usually achieved by fluorination. A common preparation method is to use benzyl alcohol as a starting substance, which undergoes a fluorination reaction to introduce fluorine atoms. Commonly used fluorinating agents include hydrogen fluoride, sodium trifluoromethanesulfonate, etc.Safety Information:2,4-Difluorobenzyl alcohol has an irritating effect on the skin and eyes of the human body under general operating conditions. Rinse immediately with clean water upon contact and follow proper safety operating procedures. It may also have some toxicity and should be operated in a well-ventilated area and avoided from inhalation and ingestion. When using or storing, the relevant safety guidelines and precautions need to be followed.
Application
2,4-Difluorobenzyl alcohol is a high-purity fluorinated aromatic intermediate widely used in pharmaceutical, agrochemical, and material science R&D. Its two fluorine atoms enhance metabolic stability, lipophilicity, and bioavailability of drug candidates. The primary alcohol group enables oxidation to aldehyde or carboxylic acid, esterification, and ether formation, facilitating rapid structure-activity relationship (SAR) studies. This versatile building block serves as a key precursor for synthesizing CNS-active agents (antidepressants, antipsychotics), kinase inhibitors, anti-inflammatory APIs, and antiviral drugs. In agrochemistry, it is utilized to develop selective herbicides, fungicides, and insecticides with improved target selectivity and environmental safety. Additionally, it finds applications in liquid crystal display materials, specialty polymers, and fluorinated fine chemicals. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2,4-difluorobenzyl alcohol with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.





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