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2-Bromofluorobenzene(CAS#1072-85-1)

Chemical Property:

Molecular Formula C6H4BrF
Molar Mass 175
Density 1.601g/mLat 25°C(lit.)
Melting Point -8°C
Boling Point 78-82°C50mm Hg
Flash Point 110°F
Water Solubility insoluble
Solubility 0.35g/l
Vapor Presure 4.67mmHg at 25°C
Appearance Liquid
Specific Gravity 1.601
Color Clear colorless to light yellow
BRN 1071819
Storage Condition Sealed in dry,Room Temperature
Refractive Index n20/D 1.534(lit.)
Physical and Chemical Properties Light yellow liquid. Boiling point 155 ℃-157 ℃, flash point 43 ℃, refractive index 1.5340, specific gravity 1.601.
Use Used as pharmaceutical, pesticide intermediates

Product Detail

Product Tags

Risk Codes R10 - Flammable
R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
S16 - Keep away from sources of ignition.
UN IDs UN 1993 3/PG 3
WGK Germany 3
RTECS DA1050000
TSCA T
HS Code 29036990
Hazard Note Flammable/Irritant
Hazard Class 3
Packing Group III

 

Introduction

O-fluorobromobenzene. It is a colorless liquid that exhibits an aromatic odor at room temperature. O-fluorobromobenzene is soluble in most organic solvents, such as ethanol, acetone and chloroform. O-fluorobromobenzene can also be used as an important component of pesticides to control pests and pathogenic microorganisms on crops. There are several ways to prepare o-fluorobromobenzene, and the common method is to produce it by the reaction of o-fluorophenyl ether and bromine. The specific steps are to first react o-fluorophenyl ether with bromine, heat it under acidic conditions, and then purify it through processes such as distillation and crystallization to obtain the final o-fluorobromobenzene product. It is an organic compound that can cause irritation and damage to the human body. During the procedure, appropriate protective gear should be worn to avoid contact with the skin, eyes, and respiratory tract. It should be operated in a well-ventilated environment, away from open flames and heat sources, to ensure safety. O-fluorobromobenzene is also a hazardous substance and should be properly stored and disposed of. Empty containers should be properly disposed of to avoid environmental pollution.

Application

2-Bromofluorobenzene (1-Bromo-2-fluorobenzene, CAS 1072-85-1) is a high-purity aromatic halide used as a fundamental building block for pharmaceutical and agrochemical synthesis. The strategic ortho-substitution pattern enables orthogonal functionalization, where the bromine undergoes selective cross-coupling reactions (Suzuki-Miyaura, Stille, Heck) and the fluorine improves metabolic stability and target binding affinity. This building block is a key pharmaceutical intermediate for the antidepressant APIs duloxetine (Cymbalta®) and fluoxetine (Prozac®), as well as antipsychotics, anti-inflammatory agents and JAK inhibitors. As an agrochemical intermediate, it is a direct precursor to the herbicide flumioxazin and triazole fungicides. Its unique chemical properties also support advanced materials, including liquid crystal displays and OLEDs. High-purity 2-Bromofluorobenzene ensures reproducible performance in high-throughput screening, SAR studies, and cGMP manufacturing. Xinchem offers reliable custom synthesis and contract manufacturing of this versatile halogenated arene to meet your pharmaceutical and agrochemical development needs. Contact us for a competitive quote.


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