3,4-Difluoro-1-BromoBenzene(CAS#18282-59-2)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S28A - |
| WGK Germany | 3 |
| TSCA | T |
| HS Code | 29039990 |
| Hazard Class | IRRITANT |
Introduction
3,4-Dichlorobromobenzene, also known as bromodichlorobenzene, is an organic compound. The following is an introduction to its properties, uses, preparation methods and safety information: Properties:- Appearance: 3,4-Dichlorobromobenzene is a colorless to pale yellow liquid. - Insoluble in water, soluble in organic solvents. Uses: It is an important chemical raw material. Preparation method:- 3,4-dichlorobromobenzene can be obtained by the reaction of bromobenzene and chlorine. The reaction conditions are generally heated and carried out under light. Safety Information:- 3,4-Dichlorobromobenzene has certain toxicity and can cause irritation and damage to the human body. Appropriate safety measures, such as wearing protective gloves, goggles, and protective clothing, must be taken when in use or in contact. - Avoid contact with skin, eyes, or mucous membranes and avoid inhaling their vapors. - In case of accidental contact or inhalation, rinse immediately with clean water and seek medical attention promptly.
Application
3,4-Difluoro-1-bromobenzene (1-bromo-3,4-difluorobenzene) is a versatile fluorinated aryl halide widely used as a building block in pharmaceutical, agrochemical, and material science research. The strategic 3,4-difluoro substitution pattern enhances metabolic stability, lipophilicity, and target binding affinity of drug candidates. The bromine atom enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to construct biaryl, heteroaryl, and alkenyl scaffolds. This intermediate is a key precursor for synthesizing kinase inhibitors (e.g., for cancer and inflammation), antiviral agents, and central nervous system (CNS) drug candidates. In agrochemical development, it is used to prepare selective herbicides, fungicides, and insecticides with improved crop protection profiles. Additionally, it serves as a monomer for liquid crystal display (LCD) materials, organic semiconductors, and specialty polymers. Its high purity ensures reproducible results in structure-activity relationship (SAR) studies, high-throughput screening, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3,4-difluoro-1-bromobenzene with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
