5-Bromophthalide(CAS#64169-34-2)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | EJ9940000 |
| HS Code | 29329990 |
Introduction
5-Bromophthalide, also known as 5-bromo-1,3-dioxane, is an organic compound. The following is an introduction to its properties, uses, preparation methods and safety information: Properties:- 5-bromophthalide is a colorless liquid with a special aroma. Uses:-5-Bromophthalide is often used as a starting material for organic synthesis in chemical laboratories. - It can be used as a reagent in a variety of organic synthesis reactions. - The peculiarities of its chemical properties, which can sometimes also be used in the preparation of other organic compounds. Preparation method: - The preparation of 5-bromophthalide can be obtained by reacting bromobenzene and 1,3-propanediol under appropriate conditions. - Reaction conditions often require the right solvent, catalyst, and appropriate temperature and reaction time. Safety Information:- When handling this compound, appropriate protective equipment such as lab gloves, safety glasses, etc., should be worn. - Avoid direct contact with the skin and rinse immediately with plenty of water if it does. - Avoid inhaling vapors or dust and pay attention to ventilation.
Application
5-Bromophthalide (CAS 64169-34-2) is a key halogenated phthalide derivative widely used as a versatile building block in pharmaceutical, agrochemical, and dye synthesis. It is the critical intermediate for producing Citalopram and Escitalopram, selective serotonin reuptake inhibitors (SSRIs) for treating major depressive disorder and anxiety. In medicinal chemistry, it is also employed to synthesize anti-inflammatory, analgesic, antimicrobial, and antineoplastic drug candidates. Beyond pharmaceuticals, 5-Bromophthalide serves as a precursor for fluorescent dyes and probes for biological imaging, diagnostics, and organic electronics. In agrochemical R&D, it is utilized to develop herbicides, fungicides, and insecticides with improved crop protection profiles. The bromine at the 5-position enables cross-coupling reactions including Suzuki-Miyaura couplings and C–C/C–N bond formations, allowing rapid library construction for SAR studies. It also acts as a sulfonylation reagent and a reactant for chiral 2-carboxy cyclic ethers. Its high purity (≥98%) ensures reproducible results in high-throughput screening and cGMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of high-purity 5-Bromophthalide with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
