p-fluorophenol(CAS#371-41-5)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2928 6.1/PG 2 |
| WGK Germany | 1 |
| RTECS | SL4550000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | T |
| HS Code | 29081000 |
| Hazard Note | Corrosive/Harmful |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
4-fluorophenol, also known as p-fluorophenol, is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 4-fluorophenol: Properties: - 4-fluorophenol is slightly soluble in water and has high solubility in organic solvents. - 4-Fluorophenol can be affected by the action of compounds such as acids, bases, oxidants and reducing agents. Usage:- It can also be used in the manufacture of chemicals such as additives, surfactants, and dyes. - 4-fluorophenol can also be used in the synthesis of pesticides and rubber preservatives. Preparation method: - 4-fluorophenol is mainly obtained by the reaction of chlorobenzene and hydrogen fluoride. The reaction is carried out in a reaction vessel, and reactants such as chlorobenzene and hydrogen fluoride are reacted under the action of a catalyst at the appropriate temperature and pressure. Safety Information:- 4-Fluorophenol is a toxic substance that has certain hazards to the human body. - May cause irritation and damage when in contact with the skin, eyes, or ingestion. - Close attention must be paid to safe handling and personal protective equipment such as safety glasses, gloves and protective clothing must be worn during use and handling. - 4-fluorophenol must be properly stored and disposed of to avoid its release into the environment, causing contamination and hazards. The correct handling method should be carried out in accordance with local regulations and relevant regulations.
Application
p-Fluorophenol (CAS 371-41-5) is a key fluorinated aromatic building block widely used in pharmaceutical, agrochemical, and material science research. It serves as a critical intermediate in the synthesis of non‑steroidal anti‑inflammatory drugs (NSAIDs) such as flurbiprofen and anti‑malarial agents, as well as various central nervous system (CNS) drug candidates. The para‑fluorine substitution enhances metabolic stability, lipophilicity, and target binding affinity. In agrochemical development, p‑fluorophenol is utilized to prepare selective herbicides, fungicides, and insecticides with improved crop protection profiles. Its reactive phenolic group enables etherification, esterification, and cross‑coupling reactions, allowing rapid structure‑activity relationship (SAR) studies and library construction. Additionally, it is employed in the production of liquid crystal display (LCD) monomers, specialty polymers, and functional coatings. High purity ensures reproducible results in high‑throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity p‑fluorophenol to meet your R&D and commercial needs. Contact us for a competitive quote and reliable global supply.







