2,5-Difluoroanisole(CAS#75626-17-4)
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1993 |
| HS Code | 29093090 |
| Hazard Note | Flammable |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2,5-Difluoroanisole(2,5-Difluoroanisole) is an organic compound with the chemical formula C7H6F2O. It is a colorless liquid with a fragrant smell. Here are some of the properties and characteristics of 2,5-Difluoroanisole:
Nature:
-The molecular weight is 146.12g/mol.
-Melting point is -34°C, boiling point is 141-142°C.
-Soluble in many organic solvents, such as ethanol, ether and benzene.
-is a non-flammable compound.
Use:
- 2,5-Difluoroanisole can be used as a reagent in organic synthesis, mainly used in aromatic alkylation reactions in organic synthesis reactions.
-In the pharmaceutical industry, it is used to synthesize active molecules in drugs.
-The compound can also be used for research purposes, for example as a nuclear magnetic resonance (NMR) solvent.
Preparation Method:
- 2,5-Difluoroanisole can be synthesized by the reaction of cresol and difluoric anhydride. Reaction conditions generally require high temperatures and the presence of a catalyst.
Safety Information:
- 2,5-Difluoroanisole may irritate eyes and skin at room temperature. Rinse with plenty of water immediately after contact.
-During operation, avoid inhaling its steam to ensure good ventilation.
-use and storage should be stored in a cool, dry, ventilated place, away from fire and oxidant.
-When handling the compound, follow the safe operating guidelines and wear appropriate protective equipment, such as gloves and goggles.
2,5-Difluoroanisole (CAS 75626-17-4) is a versatile fluorinated aromatic building block. In pharmaceutical development, it serves as a key intermediate for the synthesis of active pharmaceutical ingredients (APIs) and has been used to develop small‑molecule drugs for neurological disorders and as a precursor for antipsychotic compounds. The presence of two electron-withdrawing fluorine atoms and an electron-donating methoxy group imparts favorable metabolic stability, lipophilicity, and bioavailability, allowing the difluoroanisole motif to function as a bioisostere in drug design. In agrochemical research, this fluorinated intermediate is utilized to prepare herbicides, fungicides, and insecticides, providing effective crop protection solutions. Additionally, 2,5-Difluoroanisole supports material science applications, including the development of liquid crystals, advanced polymers, and coatings. Its predictable reactivity in electrophilic aromatic substitution and metal-catalyzed cross-couplings (e.g., Suzuki, Buchwald-Hartwig) makes it an indispensable precursor for constructing diverse chemical libraries in drug discovery and functional material design. Xinchem is a premier manufacturer and supplier of this essential building block, offering custom synthesis, custom chemical synthesis, and flexible contract manufacturing scaled from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
