3,4-Difluoroanisole(CAS#115144-40-6)
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S7/9 - |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29093090 |
| Hazard Note | Flammable |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
Application
3,4-Difluoroanisole (1,2-difluoro-4-methoxybenzene) is a high-purity fluorinated building block widely employed as a key intermediate in pharmaceutical, agrochemical, and liquid crystal R&D. In drug discovery, its unique 3,4‑difluoro substitution enhances metabolic stability, membrane permeability, and bioavailability of API candidates, and it has been utilized to develop anti‑inflammatory, analgesic, and anticancer agents with improved efficacy. In crop protection, it serves as a core precursor for herbicides (diflufenican) and insecticides (fluazifop-P-butyl), where fluorine substitution increases bioactivity and environmental safety. The compound is also a critical intermediate for manufacturing liquid crystal display (LCD) materials with superior thermal and optical stability. Additionally, it functions as a versatile synthon in cross‑couplings (Suzuki, Buchwald‑Hartwig) and methoxy‑aromatic derivatizations for constructing complex functionalized systems. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote today.
