3,5-Difluoroanisole(CAS#93343-10-3)

Introduction

3,5-Difluoroanisole. Here are some of its properties, uses, manufacturing methods, and safety information:Quality:Appearance: 3,5-Difluoroanisole is a colorless liquid.Density: about 1.20 g/cm3.Solubility: 3,5-Difluoroanisole is soluble in many organic solvents, such as ethanol and ether.Use:Chemical synthesis: 3,5-difluoroanisole can be used as a reagent in organic synthesis for the synthesis of other organic compounds.Surfactants: 3,5-Difluoroanisole can be used as a component of some surfactants.Method:The preparation of 3,5-difluoroanisole can be obtained by reacting phenol with hydrogen fluoride in an appropriate solvent. Reaction conditions are generally carried out at room temperature.Safety Information:During use or storage, it should be kept away from open flames and high temperatures, and avoid contact with oxidants and strong acids.Appropriate personal protective equipment such as gloves, protective eyewear, and respirators should be worn when handling 3,5-difluoroanisole.If you accidentally come into contact with 3,5-difluoroanisole, rinse immediately with plenty of water and seek medical treatment.

Application
3,5-Difluoroanisole (1,3-difluoro-5-methoxybenzene, CAS 93343-10-3) is a high-purity, fluorinated aromatic building block and a key intermediate for pharmaceutical, agrochemical, and material science R&D. In drug discovery, this versatile compound is used to prepare indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists for immune‑oncology, as well as imidazo[1,5‑a]pyrido[3,2‑e]pyrazines and imidazo[1,5‑a]quinoxalines as orally active phosphodiesterase 10A (PDE10A) inhibitors for CNS disorders. As a key pharmaceutical intermediate, its fluorinated structure enhances drug bioavailability and metabolic stability. In agrochemical research, 3,5-difluoroanisole serves as a core precursor for selective herbicides, insecticides, and fungicides by introducing fluoroaryl motifs that improve target selectivity and environmental safety. In advanced materials, it is employed in the synthesis of liquid crystal display (LCD) components, fluorinated polymers, and high-performance coatings with enhanced thermal and chemical resistance. Additionally, its utility as a versatile organic synthesis building block enables the introduction of fluorine and methoxy functionalities into complex molecular scaffolds. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3,5-difluoroanisole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.