2,3,4-Trifluoroanisole(CAS#203245-16-3)
| Hazard Symbols | F - Flammable |
| UN IDs | UN3271 |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2,3,4-Trifluoroanisole is an organic compound with the chemical formula C7H4F3O. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid
-Boiling point: 70-72 ° C
-density: 1.45 g/cm ^ 3
-Solubility: Soluble in organic solvents, such as ethanol, acetone and dimethylformamide.
Use:
- 2,3,4-Trifluoroanisole can be used as a reagent in organic synthesis and is widely used in the fields of medicine, pesticide and material science.
-It can be used as an intermediate in drug synthesis, for example, for the synthesis of biologically active compounds.
-The compound can act as a solvent and catalyst in some chemical reactions.
-It can also be used in fluorination reactions in organic synthesis to introduce fluorine atoms.
Method:
The preparation method of 2,3,4-Trifluoroanisole usually involves the reaction of anisole with hydrogen trifluoride:
1. First, anisole is reacted with hydrogen trifluoride under reaction conditions to obtain the trifluoride of anisole (C6H5O · 3HF).
2. Then the trifluoride of anisole is defluoridated to remove hydrogen trifluoride under alkaline conditions to obtain 2,3,4-Trifluoroanisole.
Safety Information:
- 2,3,4-Trifluoroanisole is a chemical, and safety measures should be taken when using it.
-It may be irritating and toxic and should be avoided by inhalation, contact with skin and eyes.
-When using or handling, appropriate protective measures should be taken, such as wearing protective gloves, goggles and protective clothing.
-Store away from oxidants and fire sources.
Application
2,3,4-Trifluoroanisole is a high‑purity fluorinated building block featuring a methoxy group and three fluorine atoms on an electron‑deficient benzene ring. As a key pharmaceutical intermediate, it serves as a versatile precursor for constructing heterocyclic scaffolds with enhanced bioavailability and metabolic stability. Its unique electronic properties enable selective nucleophilic aromatic substitution (SNAr) and cross‑coupling reactions, facilitating the synthesis of kinase inhibitors, antiviral agents, and anti‑inflammatory drug candidates. In agrochemical R&D, this intermediate is used to produce highly effective herbicides, fungicides, and insecticides with improved target selectivity and environmental safety profiles. The compound is also investigated for applications in liquid crystal displays (LCDs) and other optoelectronic materials, where the fluorine substituents enhance molecular ordering and dielectric anisotropy. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
