2-Chloro-6-Methyl-7H-pyrrolo[2,3-d]pyriMidine(CAS#1060816-56-9)

Introduction

2-Chloro-6-methyl-7H-pyrrolo[2,3-D]pyrimidine is an organic compound. The following is an introduction to its properties, uses, preparation methods and safety information:- Properties:- Appearance: 2-chloro-6-methyl-7H-pyrrolo[2,3-D]pyrimidine is a white to off-white solid. - Solubility: The compound has good solubility among common solvents. Usage: Method: 2-chloro-6-methyl-7H-pyrrolo[2,3-D]pyrimidine can be obtained by organic synthesis in several steps. A commonly used synthesis method is to react 5-chloro-2-methylpyrimidine with ortho-azidothione, and then further chemical reactions to obtain the target product. Safety Information: As an organic compound, it may be toxic and dangerous to humans. Appropriate safety measures should be taken when using and handling, and relevant safety operating procedures and personal protection requirements should be observed.

Application
2-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 1060816-56-9) is a pivotal pyrrolopyrimidine intermediate with proven efficacy as a potent and selective CDK4/6 inhibitor, demonstrating excellent oral bioavailability in preclinical oncology studies. It serves as a crucial pharmaceutical building block for constructing targeted anticancer agents, including inhibitors for protein kinase-associated disorders, flaviviruses (Zika and dengue), and other therapeutic targets. The chlorine atom at the 2-position enables versatile nucleophilic substitution and cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig), allowing rapid generation of diverse drug-like libraries. Xinchem offers this versatile pharmaceutical building block with GMP-grade purity (≥97%) and full analytical support. Contact us for custom synthesis, custom chemical synthesis, and contract manufacturing of 2-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, scaled reliably from R&D to commercial tons.