2,4-Difluoroanisole(CAS#452-10-8)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R10 - Flammable |
| Safety Description | S7/9 - S16 - Keep away from sources of ignition. S37 - Wear suitable gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1993 |
| HS Code | 29093090 |
| Hazard Note | Flammable |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2,4-Difluorobenzyl ether. Here are some properties of 2,4-difluorobenzyl ether:Appearance: 2,4-difluorobenzyl ether is a colorless liquid with a fragrant smell.Density: The density of 2,4-difluorobenzyl ether is about 1.36 grams per milliliter.Solubility: 2,4-difluorobenzyl ether is soluble in ether, acetone, methanol, and alcohol solvents.Uses of 2,4-difluorobenzyl ether include:Solvent in chemical reactions: 2,4-difluorobenzyl ether can be used as a reaction solvent in organic synthesis.Chemical research: 2,4-difluorobenzyl ether has significant application value in organic chemistry research.The preparation of 2,4-difluorobenzyl ether can be obtained by fluorinating 2,4-difluorobenzyl alcohol sodium or fluorinating 2,4-difluorobenzaldehyde sodium. The preparation process is relatively complex and requires organic synthesis laboratory conditions and related equipment.When using 2,4-difluorobenzyl ether, the following safety information should be noted:2,4-difluorobenzyl ether may irritate the eyes and skin, and direct contact should be avoided.Inhalation of 2,4-difluorobenzyl ether vapor should be avoided, and operations should be conducted in a well-ventilated area.Appropriate personal protective equipment, such as chemical gloves, goggles, and protective clothing, should be worn during use.Containers storing 2,4-difluorobenzyl ether should be well-sealed and kept away from fire sources and high temperatures.Note: Any chemical should be carefully reviewed with the relevant safety data sheet (MSDS) and operating manual before use to ensure the correctness of safety operations and protective measures.
Application
2,4-Difluoroanisole (2,4-Difluoro-1-methoxybenzene, CAS 452-10-8) is a versatile fluorinated building block for advanced organic synthesis, drug discovery, and material science. In pharmaceutical development, this essential pharmaceutical building block and key anti‑inflammatory intermediate is widely used to enhance the metabolic stability, bioavailability, and in vivo efficacy of APIs. Difluoroanisole is a privileged scaffold for introducing aryl‑F motifs to CNS drugs, kinase inhibitors (e.g., pacritinib), and analgesic drug candidates. In agrochemical chemistry, it serves as an essential agrochemical synthesis core and cross‑coupling precursor for selective herbicides, fungicides, and insecticides, improving lipophilicity and crop protection profiles. The compound also functions as a liquid crystal material monomer, a specialty polymer additive, and a high‑purity analytical standard. Xinchem offers high‑purity 2,4-difluoroanisole with flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing for seamless scaling from R&D to commercial tons. Contact us for a competitive quote and consistent global supply.
