2,3-Difluoroanisole(CAS#134364-69-5)

Introduction

2,3-Difluoroanisole is an organic compound with the formula C7H6F2O. The following is an introduction to the properties, uses, preparation methods and safety information of 2,3-difluoroanisole:

Nature:

-Appearance: colorless liquid

-Melting Point:-29°C

-Boiling Point: 82-83°C

-Density: 1.334g/cm³

-Solubility: Soluble in most organic solvents, such as ethanol and ether.

Use:

- 2,3-difluoroanisole is widely used in organic synthesis reactions, mainly as an important intermediate compound for the synthesis of other organic compounds.

-It can also be used as a solvent for the manufacture of paints, dyes and other chemical products.

Preparation Method:

- 2,3-Difluoroanisole is usually prepared by hydrofluorination of the benzene ring. This reaction reacts 2,3-difluorobenzyl alcohol with a suitable etherifying agent, such as p-toluenesulfonic acid or thionyl chloride, to give the corresponding etherified product.

Safety Information:

- 2,3-difluoroanisole should be used carefully and avoid contact with skin, eyes and respiratory tract.

-Use appropriate personal protective equipment such as gloves, safety goggles and face shields when operating.

-Avoid breathing its vapors and provide adequate ventilation.

-Please pay attention to fire prevention and electrostatic discharge during storage and handling.

-When there is an allergic reaction or discomfort, please stop using it immediately and seek medical attention in time.

Application
2,3-Difluoroanisole (CAS 134364-69-5) is a high-purity fluorinated aromatic ether widely used as a versatile building block in pharmaceutical and agrochemical research. Its unique 2,3-difluoro substitution pattern enhances metabolic stability, lipophilicity, and bioavailability of drug candidates, making it a key pharmaceutical intermediate for the synthesis of anti-inflammatory, anticancer, and CNS-active APIs. In crop protection, this intermediate serves as a core precursor for selective herbicides, fungicides, and insecticides, where the fluorine atoms improve target selectivity and environmental safety. The methoxy group enables further functionalization via demethylation or cross-coupling reactions. 2,3-Difluoroanisole also finds applications in liquid crystal materials, fluorinated polymers, and specialty solvents. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and dependable global supply.