2,5-Difluorobenzyl chloride(CAS#495-07-8)

Chemical Property:

Molecular Formula	C7H5ClF2
Molar Mass	162.56
Density	1.294±0.06 g/cm3(Predicted)
Boling Point	74°C/20mmHg(lit.)
Flash Point	61.3°C
Vapor Presure	1.69mmHg at 25°C
Appearance	clear liquid
Color	Colorless to Light yellow to Light orange
Storage Condition	2-8°C
Sensitive	Lachrymatory
Refractive Index	1.4920 to 1.4960
MDL	MFCD01090989

Send email to us

Product Detail

Product Tags

Risk Codes	R34 - Causes burns R20/22 - Harmful by inhalation and if swallowed.
Safety Description	S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN1760
HS Code	29039990
Hazard Note	Corrosive/Lachrymatory
Hazard Class	8
Packing Group	III

Introduction

2,5-Difluorobenzyl chloride is an organic compound with the chemical formula C7H5ClF2. It is a colorless and transparent liquid with a pungent odor.

2,5-Difluorobenzyl chloride has a wide range of applications in organic synthesis. It can be used as a reagent for the synthesis of other organic compounds, such as as an important intermediate synthesis of aromatic amines, aromatic ethers and aromatic alcohols and other organic compounds. In addition, it can also be used in the production of pesticides and drugs, and has important industrial and scientific research value.

Preparation of 2,5-Difluorobenzyl chloride can be obtained by reacting 2,5-difluorobenzyl alcohol with thionyl chloride. As the reaction proceeds, the alcohol reacts with thionyl chloride to give 2,5-difluorobenzyl sulfoxide, which then reacts with hydrogen chloride to give the target product, 2,5-Difluorobenzyl chloride.

Pay attention to safety when using 2,5-Difluorobenzyl chloride. It is irritating and corrosive and may cause damage to the eyes, skin and respiratory system. During operation, appropriate protective equipment, such as safety glasses, gloves and protective masks, should be worn to ensure a well-ventilated experimental environment. Avoid contact with oxidants, strong acids and strong bases. In case of contact or inhalation, please wash or seek medical help.

Application

2,5-Difluorobenzyl chloride is a versatile fluorinated building block widely used as a key intermediate in pharmaceutical and agrochemical research. Its reactive chloromethyl group enables efficient nucleophilic substitution reactions with amines, alcohols, and thiols, allowing rapid introduction of the 2,5-difluorobenzyl motif into drug candidates. The strategic placement of two fluorine atoms enhances metabolic stability, lipophilicity, and target binding affinity. This compound serves as a critical precursor for the synthesis of anticancer and anti-inflammatory APIs, as well as kinase inhibitors and CNS-active agents. In crop protection, it is employed to develop selective herbicides, fungicides, and insecticides with improved biological efficacy and environmental safety. The compound also participates in palladium-catalyzed cross-coupling reactions and can be oxidized to the corresponding aldehyde or carboxylic acid for further derivatization. In material science, it is used to prepare specialty polymers, liquid crystal displays (LCDs), and functional coatings with enhanced chemical resistance and thermal stability. High purity ensures reproducible results in SAR studies, high-throughput screening, and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of this essential building block from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.