(2E,4E)-Octa-2,4-dien-1-ol（CAS#18409-20-6）

Safety & Storage
‌GHS Pictogram‌: GHS07 (Warning)
‌Hazard Statements‌:
H227: Combustible liquid
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
‌Personal Protection‌: Wear ‌safety goggles and gloves‌, avoid inhalation of vapor or skin contact
‌Storage Conditions‌: Store ‌sealed, away from light, in dry conditions at room temperature‌ to prevent oxidation
‌WGK Germany‌: Not explicitly listed, but similar compounds are typically classified as ‌WGK 3‌ (severe hazard to aquatic environment)
Uses & Applications
‌Fragrance & Flavor‌:
Used in ‌chicken, fatty, and creamy-type flavor formulations‌, widely applied in meat products, instant foods, and seasonings to enhance authenticity and flavor depth
Listed as ‌JECFA No. 1180‌, approved for food flavoring use
‌Food Additive‌:
Listed as ‌FEMA GRAS‌ (FEMA 3956), approved for use as a food flavoring agent
Naturally present in heated meats and lipid degradation products, formed during the Maillard reaction
‌Research & Intermediate‌:
Serves as an ‌organic synthesis intermediate‌ for constructing complex fragrance molecules or bioactive compounds
Used in ‌olfactory receptor studies and flavor metabolic pathway analysis‌ in life science research
‌Industrial Raw Material‌:
Can be used to synthesize ‌ester derivatives‌, such as ‌(2E,4E)-2,4-octadienyl acetate‌, for advanced fragrance applications
Synthesis Method
Under argon atmosphere and at -78 °C, diisobutylaluminum hydride (DIBAL-H) is slowly added to a solution of a specific ester (CAS: 64713-73-1) in anhydrous dichloromethane. After reaction completion, the mixture is quenched with 10% NaOH solution, warmed to room temperature, and stirred for 1 hour. The organic layer is separated, extracted with DCM, washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product is purified by flash column chromatography to yield the target compound.
⚠️ ‌Note‌: This product is a chemical substance, ‌not for direct consumption or medicinal use‌. For industrial, research, or flavor formulation purposes only. Purchase requires appropriate qualifications.