3-Chloro-N,N-dimethylpropan-1-aminehydrochloride(CAS#5407-04-5)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | UI0209950 |
| FLUKA BRAND F CODES | 3 |
3-Chloro-N,N-dimethylpropan-1-aminehydrochloride(CAS#5407-04-5)
quality
Colorless crystals. Melting point 141~144 °C.
Method
Dimethylamine and propenol were sent into the reaction tank in the presence of sodium hydroxide at a temperature of 130~150 °C and 127. 5~147. Synthesis under pressure under lkPa pressure, 1-methylaminopropyl-3-ol was prepared by reflux for 14 hours, and then chlorinated with thionyl chloride, and 1--methylamino-3-chloropropane hydrochloride was obtained by reacting at a temperature of 55~90 °C for 9~10 hours.
use
This product is an intermediate in the production of the drug chlorpromazine.
security
This product is corrosive. Operators should wear protective equipment. It is packed in ceramic jars, 25kg per can, and is protected by a wooden frame.
Application
3-Chloro-N,N-dimethylpropan-1-amine hydrochloride is a versatile tertiary amine intermediate widely used in pharmaceutical and agrochemical synthesis. Its primary application is as a key building block for the preparation of various bioactive compounds, including antifungal agents (e.g., naftifine), antihistamines (e.g., pheniramine), and local anesthetics. The chloropropyl chain serves as an efficient alkylating reagent for introducing the (N,N-dimethylaminopropyl) moiety into drug candidates via nucleophilic substitution. In organic synthesis, this hydrochloride salt is employed to construct tertiary amine-containing scaffolds for CNS drugs and antiemetics. Beyond pharmaceuticals, it is utilized in the production of surfactants, corrosion inhibitors, and phase-transfer catalysts. Its stable crystalline form ensures easy handling and storage. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
