(3aS,4R,5S,6aR)-(+)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one(CAS#76704-05-7)

Introduction

(3aS,4R,5S,6aR)-(+)-Hexahydro-5-hydroxy-4-hydroxymethyl-2H-cyclopentano[b]furan-2-one, also known as 2H-cyclopentano[b]furan-2-one, is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of the substance:Properties:- Appearance: colorless crystalline solid- Thermal stability: stable, not easy to decompose- Solubility: soluble in organic solvents such as ethanol, chloroform, dichloromethane, insoluble in waterUse: Preparation method: Hexahydro-5-hydroxy-4-hydroxymethyl-2H-cyclopentano[b]furan-2-one can be synthesized by a variety of methods, one of which is the use of hydrogenation reduction and selective oxidation reaction. Safety Information:- The substance is less toxic, but general safety operating procedures should still be followed. - Avoid contact with skin, eyes, and respiratory tract during operation, and pay attention to protective measures, such as wearing protective gloves, goggles, and protective masks. - It should be placed in a dry, well-ventilated place, away from heat and fire sources, and avoid contact with oxidants. - Care should be taken to avoid vibrations and collisions during storage and handling.

Application
It is (+)-Corey lactone (also known as (+)-Corey lactone diol), a chiral, bicyclic γ-lactone derivative. This compound is a crucial chiral building block and key intermediate in the total synthesis of prostaglandins (PGs) and their analogs, widely applied in pharmaceutical research, drug development, and organic synthesis.