page_banner

product

4-Bromo-2-methylpyrimidine(CAS#1114560-76-7)

Chemical Property:

Molecular Formula C5H5BrN2
Molar Mass 173.01
Density 1.596±0.06 g/cm3(Predicted)
Boling Point 195.2±13.0 °C(Predicted)
pKa 0.27±0.20(Predicted)
Storage Condition Inert atmosphere,Store in freezer, under -20°C

Product Detail

Product Tags

 

Introduction

4-Bromo-2-methylpyrimidine is an organic compound. The following is a detailed introduction to the properties, uses, preparation methods and safety information of 4-bromo-2-methylpyrimidine:Quality:4-Bromo-2-methylpyrimidine is a solid with a peculiar odor. It is slightly soluble in water but readily soluble in organic solvents such as alcohols, ethers, and ketones. The molecular structure of 4-bromo-2-methylpyrimidine contains bromine atoms and methyl groups, which make it reactive in organic synthesis.Use:4-Bromo-2-methylpyrimidine can be used as an intermediate in organic synthesis. It can also be used in the preparation of high-performance polymer materials, such as liquid crystal polymers.Method:A common method for the preparation of 4-bromo-2-methylpyrimidine is by the reaction of isobutylene and hydrobromic acid. The specific steps are to first heat and react isobutylene with hydrobromic acid to produce 4-bromo-2-methyl-3-butene. Then, 4-bromo-2-methyl-3-butene is reacted with ammonia to produce 4-bromo-2-methylpyrimidine.Safety Information: It is a flammable substance and should be avoided from contact with open flames and high temperatures. Prevent it from coming into contact with skin and eyes, and if contact occurs, rinse the area immediately with plenty of water. To avoid inhaling its dust, a suitable protective mask should be worn. When storing and transporting 4-bromo-2-methylpyrimidine, make sure the container is tightly closed and stored in a cool, dry place, away from ignition and oxidants.

Application
4-Bromo-2-methylpyrimidine (CAS 1114560-76-7) is a key heterocyclic building block widely used in medicinal chemistry and drug discovery. Its pyrimidine core serves as a privileged scaffold in bioactive molecules, and the bromine at the 4-position enables efficient cross-coupling (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for rapid structure–activity relationship (SAR) studies. This intermediate is used to synthesize 2-methyl-4-pyrimidinyl-boronic acid, a precursor for indazole-derived antimicrobial inhibitors, as well as pyridinylimidazole-type p38α mitogen-activated protein kinase (MAPK) inhibitors for inflammatory diseases. It also plays a role in developing PI3K inhibitors for oncology and other anticancer candidates. Beyond pharmaceuticals, it serves as a versatile organic synthetic intermediate for high-performance materials such as crown-ester-bipyridines, viologens, and liquid crystal polymers. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-Bromo-2-methylpyrimidine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote.


  • Previous:
  • Next:

  • Write your message here and send it to us