4-Chloro-2-fluoro-1-nitrobenzene(CAS#700-37-8)

Introduction

It is an organic compound with the chemical formula of C6H3ClFNO2. The following is a description of its nature, use, preparation and safety information:

Nature:

-Appearance: It is a white crystalline solid.

-Solubility: It has a certain solubility in common organic solvents, such as ethanol, dimethylformamide and chloroform.

-Melting point and boiling point: Its melting point is 55-57°C, and its boiling point is 158-161°C.

-Density: Its density is 1.57g/cm³.

Use:

-is an organic synthesis intermediate that can be used to synthesize other organic compounds, such as pesticides, fluorescent dyes and pharmaceuticals.

-It can also be used for the preparation of resistors and other devices in the electrochemical field.

Preparation Method:

can be synthesized by nitration reaction. First, it reacts with concentrated nitric acid, and nitrates under appropriate conditions to form a phosphonium salt.

Safety Information:

-is an organic compound with certain toxicity and irritation. Exposure to or inhalation of a high concentration of the metal may cause harm to human health, care should be taken to avoid contact with the skin, eyes and respiratory tract.

-When using and handling, wear appropriate protective equipment, such as chemical protective gloves, safety glasses and respiratory protective equipment.

-During use and storage, keep away from fire sources and open flames to avoid high temperatures and sparks. Wastes and residues should be disposed of in accordance with relevant regulations.

Application
4-Chloro-2-fluoro-1-nitrobenzene (CAS 700-37-8) is a multifunctional halogenated nitroarene widely used as a key building block in pharmaceutical and agrochemical research. Its unique substitution pattern—featuring electron-withdrawing nitro, chloro, and fluoro groups—enables regioselective nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-coupling reactions. This intermediate serves as a critical precursor for the synthesis of potent antimicrobial, anti-inflammatory, and anticancer agents, as well as selective herbicides and fungicides. In drug discovery, it allows rapid construction of diverse heterocyclic libraries, including benzimidazoles, quinolines, and pyrimidines. The fluoro substituent enhances metabolic stability and lipophilicity, improving drug-like properties. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.