4′-Chloro-2′-hydroxyacetophenone(CAS#6921-66-0)

Introduction

4 '-Chloro-2'-hydroxyacetophenone is an organic compound with the formula C8H7ClO2 and a molecular weight of 170.59g/mol. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:

- 4 '-Chloro-2'-hydroxyacetophenone is a white crystalline solid.

-It is stable at room temperature and not volatile.

-The compound is insoluble in water, but soluble in organic solvents such as ethanol, ether and chloroform.

Use:

- 4 '-Chloro-2'-hydroxyacetophenone is used as an important intermediate in organic synthesis.

-It can be used to synthesize other organic compounds, such as drugs, dyes and pesticides.

-The compound also has biological activities such as antibacterial, antioxidant and anti-inflammatory, so it is also used in the field of medicine.

Preparation Method:

The synthesis method of -4 '-Chloro-2'-hydroxyacetophenone can be achieved by the hydrochloric acid esterification reaction of benzophenone, and then the hydroxylation reaction.

-Specific synthetic methods can be consulted in chemical synthesis manuals or professional research papers.

Safety Information:

- 4 '-Chloro-2'-hydroxyacetophenone has low toxicity, but attention should be paid to rational use and storage.

-Wear appropriate personal protective equipment such as gloves and goggles when using.

-Avoid direct contact with skin and eyes, and avoid inhalation or ingestion of the compound.

-When using or storing, keep it away from fire and high temperature environment.

-If it enters the eyes or skin by accident, rinse immediately with plenty of water and seek medical help. If ingested by accident, seek medical attention promptly.

Application
4'-Chloro-2'-hydroxyacetophenone (CAS 6921-66-0) is a versatile halogenated phenol derivative widely used as a key pharmaceutical intermediate and organic building block. It is the core precursor for synthesizing flufenzine (a GABA antagonist insecticide) and is instrumental in the production of 2-(4-chlorophenyl)benzoxazole, a pharmacophore with potent antimicrobial and antifungal activity. This compound also serves as a critical intermediate in the synthesis of various antifungal agents, including fluconazole analogs, and plays a role in preparing bioactive molecules with anticancer and anti-inflammatory properties. Its unique ortho-hydroxy and para-chloro substitution pattern enables regioselective functionalization, making it a valuable scaffold in medicinal chemistry for constructing heterocyclic libraries. In agrochemical R&D, it is used to develop effective crop protection agents. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4'-chloro-2'-hydroxyacetophenone with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.