5-broMo-3-chloroisoquinoline(CAS#1029720-67-9)
Introduction
5-Bromo-3-chloroisoquinoline is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of this compound:Quality:- Appearance: 5-Bromo-3-chloroisoquinoline is a white solid.- Solubility: It can be dissolved in organic solvents such as ether and chloroform.Use:Method:5-Bromo-3-chloroisoquinoline can be synthesized by:Starting with quinoline, the functional groups of bromine and chlorine are introduced by chemical reactions.Secondly, the bromine and chlorine compounds are reacted with appropriate conditions and reactants to obtain 5-bromo-3-chloroisoquinoline.Safety Information:The safety information of 5-bromo-3-chloroisoquinoline has not been reported in detail, and its safety needs to be carefully evaluated according to the synthesis process and experimental conditions before use. Safe operating procedures in chemical laboratories should be followed and appropriate personal protective equipment should be worn during use. In case of any accidents or discomforts, seek medical advice promptly.
Application
5-Bromo-3-chloroisoquinoline (CAS 1029720-67-9) is a high-purity dihalogenated isoquinoline derivative featuring orthogonal bromine and chlorine leaving groups. This versatile heterocyclic building block enables sequential, site-selective palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) and nucleophilic aromatic substitutions, allowing rapid construction of polysubstituted isoquinoline libraries for structure-activity relationship (SAR) studies. As a key intermediate in medicinal chemistry, it is widely used for the synthesis of potent kinase inhibitors targeting cancer (e.g., PI3K, mTOR, DNA topoisomerases), inflammatory diseases, and neurological disorders. It also serves as a scaffold for antiviral, antimicrobial, and anti-inflammatory agents, as well as for fluorescent probes and agrochemicals. Its rigid, planar structure enhances target binding affinity and metabolic stability. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this advanced pharmaceutical core with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
