8-bromo-1,2,3,4-tetrahydroisoquinoline,hydrochloride(CAS#1159813-53-2)

Introduction

8-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride is an organic compound. It is a white to pale yellow solid that is soluble in water and organic solvents.This compound is commonly used in organic synthesis as an intermediate or reducing agent. It can also be used as a building block for bioactive macromolecules.The preparation of 8-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride is generally obtained by reacting 1,2,3,4-tetrahydroisoquinoline with bromine, and then reacting with hydrochloric acid to prepare the hydrochloride.It should be kept away from heat sources and open flames and stored in a dry, clean, well-ventilated place. When operating, appropriate protective equipment such as protective eyewear, gloves and protective clothing should be worn. In case of accidental contact with this compound, rinse immediately with plenty of water and seek medical attention. When handling and disposing of it, it should be done in accordance with local regulations.

Application
8-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS 1159813-53-2) is a high-purity brominated tetrahydroisoquinoline (THIQ) derivative supplied as a stable hydrochloride salt. This privileged heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research for the synthesis of central nervous system (CNS) agents, including potential therapeutics for Parkinson’s disease, Alzheimer’s disease, depression, and anxiety disorders. The bromine at the 8-position enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for rapid diversification in structure-activity relationship (SAR) studies. The THIQ core is a common scaffold in drug discovery, also serving as a key intermediate for kinase inhibitors (e.g., CDK, PI3K, and B-Raf), GPCR modulators, and neuroprotective agents. Its hydrochloride salt form improves water solubility and handling stability. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.