5-Bromo-7-azaindole(CAS#183208-35-7)
183208-35-7 – Risk and Safety
| Risk Codes | R22 – Harmful if swallowed R41 – Risk of serious damage to eyes |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 – Wear eye / face protection. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
183208-35-7 – Reference Information
| LogP | 1.8 at 25℃ and pH7 |
| Introduction | 7-azafindole is an important class of compounds, similar in structure to indole and purine. Its derivatives have the activity of inhibiting a variety of proteases, which has potential biological and medicinal value, so it is widely used in medical research.
5-bromo-7-azaindole is a drug intermediate for the development of new anti-tumor drugs, although there are many ways to synthesize 5-bromo-7-azaindole, such as 2-aminopyridine as raw material, through bromination, coupling, ring closure, but its reaction process is complicated, requires a lot of bromine, the cost is too high, and the reaction yield is low, not suitable for large-scale industrial production. |
| application | 5-bromo-7-azafindole is an intermediate in laboratory organic synthesis and chemical medicine research and development. it is mainly used as an intermediate for bulk drug vilafenib and an intermediate for ABT199. |
| Preparation | 2-amino-3-methyl-5-bromopyridine generates 2-nitro-3-methyl-5-bromopyridine under the oxidation of Carlo acid, and then generates intermediate 3 under the action of tetrahydropyrrole and N,N-dimethylformamide dimethylacetal (DMF-DMA), finally, under the action of Raney nickel/85% hydrazine hydrate system or other base metal, the ring is reduced to form 5-bromo-7-azaindole. |
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