5-Bromo-7-azaindole(CAS#183208-35-7)

Product Detail

Risk Codes	R22 – Harmful if swallowed R41 – Risk of serious damage to eyes
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 – Wear eye / face protection.
WGK Germany	3
HS Code	29339900
Hazard Class	IRRITANT

LogP	1.8 at 25℃ and pH7
Introduction	7-azafindole is an important class of compounds, similar in structure to indole and purine. Its derivatives have the activity of inhibiting a variety of proteases, which has potential biological and medicinal value, so it is widely used in medical research. 5-bromo-7-azaindole is a drug intermediate for the development of new anti-tumor drugs, although there are many ways to synthesize 5-bromo-7-azaindole, such as 2-aminopyridine as raw material, through bromination, coupling, ring closure, but its reaction process is complicated, requires a lot of bromine, the cost is too high, and the reaction yield is low, not suitable for large-scale industrial production.
application	5-bromo-7-azafindole is an intermediate in laboratory organic synthesis and chemical medicine research and development. it is mainly used as an intermediate for bulk drug vilafenib and an intermediate for ABT199.
Preparation	2-amino-3-methyl-5-bromopyridine generates 2-nitro-3-methyl-5-bromopyridine under the oxidation of Carlo acid, and then generates intermediate 3 under the action of tetrahydropyrrole and N,N-dimethylformamide dimethylacetal (DMF-DMA), finally, under the action of Raney nickel/85% hydrazine hydrate system or other base metal, the ring is reduced to form 5-bromo-7-azaindole.