5-Chloroindole-3-carboxylic acid(CAS#10406-05-0)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
Introduction
acid is an organic compound with the chemical formula C9H6ClNO2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-acid is a white crystalline solid.
-It has an indole ring and a carboxylic acid group.
-It is stable at room temperature, but may decompose under high temperature and light conditions.
-The melting point of the compound is 185-187°C.
Use:
-the acid is often used as a starting material for organic synthesis.
-It can be used to synthesize various indole-related compounds, such as drugs, dyes and pesticides.
Method:
-or acid can be synthesized by the chlorination reaction of indole. The specific synthesis method can be carried out by chlorinating indole, then reacting chlorinated indole with sodium cyanide, and then acid hydrolysis to get acid.
Safety Information:
-acid belongs to general laboratory chemicals.
-Wear protective glasses and gloves during operation.
-Avoid inhalation, ingestion or contact with skin.
-The toxicological data on this compound is limited, so appropriate protective measures need to be taken when using it.
Application
5-Chloroindole-3-carboxylic acid (CAS 10406-05-0) is a functionalized indole derivative bearing a chlorine atom at the 5-position and a carboxylic acid at the 3-position. This versatile heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research for the synthesis of bioactive molecules, including antiviral, anticancer, anti-inflammatory, and antimicrobial agents. The carboxylic acid enables amide or ester conjugation, while the chlorine allows cross-coupling reactions (Suzuki, Buchwald-Hartwig) to introduce diverse substituents. As an indole scaffold, it facilitates the development of selective kinase inhibitors, serotonin receptor modulators, and HIV integrase inhibitors. Its derivatives also show potential in treating neurological disorders and metabolic diseases. High purity ensures reproducible results in drug discovery and SAR studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 5-chloroindole-3-carboxylic acid with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
