7-BROMO-2,4-DIAMINOQUINAZOLINE(CAS#137553-43-6)
Introduction
7-Bromo-2,4-diaminoquinazoline is an organic compound.Quality:- Appearance: 7-bromo-2,4-diaminoquinazoline is a white solid.- Solubility: Soluble in organic solvents, such as ethanol, dimethylformamide, etc.Use:Method:- 7-Bromo-2,4-diaminoquinazoline can be synthesized by the following steps: 2,4-diaminoquinazoline is reacted with sodium nitrite and hydrochloric acid to form 2-nitro-4-aminoquinazoline; Next, 2-nitro-4-aminoquinazoline is reacted with bromide to produce 7-bromo-2,4-diaminoquinazoline.Safety Information:- There is no specific safety information for 7-bromo-2,4-diaminoquinazoline. As an organic compound, it may cause certain harm to the human body and the environment. During use, appropriate precautions should be taken to avoid direct contact with the skin and inhalation of gases. It also needs to be properly handled and stored in accordance with laboratory and safety management regulations. In research and application, there are also relevant regulations and guidelines that need to be followed. If necessary, further safety assessments should be conducted.
Application
7-Bromo-2,4-diaminoquinazoline (CAS 137553-43-6) is a functionalized quinazoline derivative bearing two amino groups at the 2- and 4-positions and a bromine at the 7-position. This privileged heterocyclic scaffold is widely used in medicinal chemistry for the synthesis of potent tyrosine kinase inhibitors, particularly targeting EGFR, HER2, and VEGFR in non‑small cell lung cancer, breast cancer, and other solid tumors. The bromine enables cross‑coupling reactions (Suzuki, Buchwald‑Hartwig) for late‑stage diversification, while the 2,4‑diamino motif allows additional amide or urea formation. This building block is also utilized in developing antiviral, anti‑inflammatory, and antimicrobial agents. High purity ensures reproducible results in high‑throughput screening, SAR studies, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
